蜗牛：不止 EMT。
Snail: More than EMT.
机构信息
Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, Lexington, KY, USA.
出版信息
Cell Adh Migr. 2010 Apr-Jun;4(2):199-203. doi: 10.4161/cam.4.2.10943. Epub 2010 Apr 14.
Abstract
Snail has moved into the fast lane of development and cancer biology with the epithelial-mesenchymal transition (EMT) emerging as one of the hottest topics in medical science within the past few years. Snail not only acts primarily as a key inducer of EMT but also plays an important role in cell survival, immune regulation and stem cell biology. This review focuses on the regulation of Snail and discusses the EMT-dependent and -independent functions of Snail in development and disease. Understanding the regulation and functional roles of Snail will shed new light on the mechanism of tumor progression and the development of novel cancer therapies.
摘要
蜗牛在发育和癌症生物学领域飞速发展，上皮-间充质转化 (EMT) 成为近年来医学科学领域最热门的话题之一。蜗牛不仅主要作为 EMT 的关键诱导因子起作用，而且在细胞存活、免疫调节和干细胞生物学中也发挥着重要作用。本文重点讨论了 Snail 的调控，并讨论了 Snail 在发育和疾病中的 EMT 依赖性和非依赖性功能。了解 Snail 的调控和功能作用将为肿瘤进展的机制和新型癌症治疗方法的发展提供新的思路。
相似文献
1
Snail: More than EMT.
Cell Adh Migr. 2010 Apr-Jun;4(2):199-203. doi: 10.4161/cam.4.2.10943. Epub 2010 Apr 14.
2
Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions.
Cells Tissues Organs. 2007;185(1-3):73-84. doi: 10.1159/000101306.
3
Cyclooxygenase-2 expression is related to the epithelial-to-mesenchymal transition in human colon cancers.
Yonsei Med J. 2009 Dec 31;50(6):818-24. doi: 10.3349/ymj.2009.50.6.818. Epub 2009 Dec 18.
4
Snail is required for transforming growth factor-beta-induced epithelial-mesenchymal transition by activating PI3 kinase/Akt signal pathway.
Biochem Biophys Res Commun. 2007 Feb 9;353(2):337-43. doi: 10.1016/j.bbrc.2006.12.035. Epub 2006 Dec 14.
5
Alcohol stimulates activation of Snail, epidermal growth factor receptor signaling, and biomarkers of epithelial-mesenchymal transition in colon and breast cancer cells.
Alcohol Clin Exp Res. 2010 Jan;34(1):19-31. doi: 10.1111/j.1530-0277.2009.01061.x. Epub 2009 Oct 23.
6
Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.
Cancer Res. 2006 Oct 1;66(19):9543-56. doi: 10.1158/0008-5472.CAN-06-0479.
7
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition.
Nat Cell Biol. 2004 Oct;6(10):931-40. doi: 10.1038/ncb1173. Epub 2004 Sep 26.
8
Time-resolved analysis of transcriptional events during SNAI1-triggered epithelial to mesenchymal transition.
Biochem Biophys Res Commun. 2009 Aug 7;385(4):485-91. doi: 10.1016/j.bbrc.2009.05.025. Epub 2009 May 12.
9
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition.
J Cell Biol. 2005 Jan 3;168(1):29-33. doi: 10.1083/jcb.200409067.
10
Protein kinase D1 suppresses epithelial-to-mesenchymal transition through phosphorylation of snail.
Cancer Res. 2010 Oct 15;70(20):7810-9. doi: 10.1158/0008-5472.CAN-09-4481. Epub 2010 Oct 12.
引用本文的文献
1
Network motifs and hypermotifs in TGFβ-induced epithelial to mesenchymal transition and metastasis.
Front Syst Biol. 2023 Mar 3;3:1099951. doi: 10.3389/fsysb.2023.1099951. eCollection 2023.
2
Differential Effects of Snail-KO in Human Breast Epithelial Cells and Human Breast Epithelial × Human Breast Cancer Hybrids.
Int J Mol Sci. 2025 Jul 22;26(15):7033. doi: 10.3390/ijms26157033.
3
Epithelial-mesenchymal transition in colorectal cancer metastasis and progression: molecular mechanisms and therapeutic strategies.
Cell Death Discov. 2025 Jul 22;11(1):336. doi: 10.1038/s41420-025-02593-8.
4
Comprehensive Computational Assessment of SNAI1 and SNAI2 in Gastric Cancer: Linking EMT, Tumor Microenvironment, and Survival Outcomes.
Cancer Inform. 2025 Jun 30;24:11769351251352892. doi: 10.1177/11769351251352892. eCollection 2025.
5
β-catenin as a key regulator of the cisplatin response in tumor cells.
Clin Exp Med. 2025 Jun 15;25(1):206. doi: 10.1007/s10238-025-01757-1.
6
Patient-Derived Colorectal Cancer Extracellular Matrices Modulate Cancer Cell Stemness Markers.
Int J Mol Sci. 2025 Mar 22;26(7):2890. doi: 10.3390/ijms26072890.
7
Breast cancer cell resistance to hormonal and targeted therapeutics is correlated with the inactivation of the NR6A1 axis.
Cancer Drug Resist. 2024 Nov 23;7:48. doi: 10.20517/cdr.2024.69. eCollection 2024.
8
Activating Invasion and Metastasis in Small Cell Lung Cancer: Role of the Tumour Immune Microenvironment and Mechanisms of Vasculogenesis, Epithelial-Mesenchymal Transition, Cell Migration, and Organ Tropism.
Cancer Rep (Hoboken). 2024 Oct;7(10):e70018. doi: 10.1002/cnr2.70018.
9
Expression of , , and in Melanoma Genesis and Progression.
Cells. 2024 Aug 29;13(17):1450. doi: 10.3390/cells13171450.
10
Regulation of the Lewis Blood Group Antigen Expression: A Literature Review Supplemented with Computational Analysis.
Transfus Med Hemother. 2024 Jun 19;51(4):225-236. doi: 10.1159/000538863. eCollection 2024 Aug.
本文引用的文献
1
Beyond epithelial to mesenchymal transition: a novel role for the transcription factor Snail in inflammation and wound healing.
J Gastrointest Surg. 2010 Feb;14(2):388-97. doi: 10.1007/s11605-009-1068-3. Epub 2009 Oct 24.
2
Neural stem cell transcriptional networks highlight genes essential for nervous system development.
EMBO J. 2009 Dec 16;28(24):3799-807. doi: 10.1038/emboj.2009.309.
3
Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells.
Stem Cells. 2009 Sep;27(9):2059-68. doi: 10.1002/stem.154.
4
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.
Cancer Cell. 2009 May 5;15(5):416-28. doi: 10.1016/j.ccr.2009.03.016.
5
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells.
Cancer Cell. 2009 Mar 3;15(3):195-206. doi: 10.1016/j.ccr.2009.01.023.
6
Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation.
EMBO J. 2009 Mar 18;28(6):686-96. doi: 10.1038/emboj.2009.23. Epub 2009 Feb 5.
7
Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs.
J Cell Biol. 2009 Feb 9;184(3):399-408. doi: 10.1083/jcb.200810113. Epub 2009 Feb 2.
8
Snail expression is an independent predictor of tumor recurrence in superficial bladder cancers.
Urol Oncol. 2010 Nov-Dec;28(6):591-6. doi: 10.1016/j.urolonc.2008.11.005. Epub 2009 Jan 22.
9
Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.
Cancer Res. 2008 Jun 15;68(12):4541-50. doi: 10.1158/0008-5472.CAN-07-6345.
10
Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes.
Cancer Res. 2008 Jun 15;68(12):4525-30. doi: 10.1158/1078-0432.CCR-07-6735.
Zotero 插件