HIV RNA 水平在早期感染中可由传播源中的病毒载量预测。
HIV RNA level in early infection is predicted by viral load in the transmission source.
机构信息
HIV/AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, CA 94110, USA.
出版信息
AIDS. 2010 Apr 24;24(7):941-5. doi: 10.1097/QAD.0b013e328337b12e.
Abstract
OBJECTIVE
HIV-1 viral load in early infection predicts the risk of subsequent disease progression but the factors responsible for the differences between individuals in viral load during this period have not been fully identified. We sought to determine the relationship between HIV-1 RNA levels in the source partner and recently infected recipient partners within transmission pairs.
METHODS
We recruited donor partners of persons who presented with acute or recent (<6 months) HIV infection. Transmission was confirmed by phylogenetic comparison of virus sequence in the donor and recipient partners. We compared viral load in the donor partner and the recipient in the first 6 months of HIV infection.
RESULTS
We identified 24 transmission pairs. The median estimated time from infection to evaluation in acutely/recently infected recipient individuals was 72 days. The viral load in the donor was closely associated with viral load at presentation in the recipient case (r = 0.55, P = 0.006).
CONCLUSION
The strong correlation between HIV-1 RNA levels within HIV transmission pairs indicates that virus characteristics are an important determinant of viral load in early HIV infection.
摘要
目的
HIV-1 病毒载量在早期感染中可预测随后疾病进展的风险，但导致个体在该时期病毒载量差异的因素尚未完全确定。我们旨在确定传播对中 HIV-1 病毒载量处于早期感染的源伴侣和新感染的受体伴侣之间的关系。
方法
我们招募了具有急性或近期（<6 个月）HIV 感染的个体的供体伴侣。通过对供体和受体伴侣病毒序列的系统发生比较来确认传播。我们比较了 HIV 感染的前 6 个月中供体伴侣和受体的病毒载量。
结果
我们确定了 24 个传播对。在急性/近期感染的受体个体中，从感染到评估的中位估计时间为 72 天。供体中的病毒载量与受体病例中的初始病毒载量密切相关（r = 0.55，P = 0.006）。
结论
HIV 传播对中 HIV-1 RNA 水平之间的强相关性表明，病毒特征是 HIV 早期感染中病毒载量的重要决定因素。
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