原发性乳腺ALK阳性间变性大细胞淋巴瘤：一例报告并文献复习

Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature.

作者信息

Daneshbod Yahya, Oryan Ahmad, Khojasteh Habib N, Rasekhi Alireza, Ahmadi Nasrollah, Mohammadianpanah Mohammad

机构信息

Department of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

J Pediatr Hematol Oncol. 2010 Mar;32(2):e75-8. doi: 10.1097/MPH.0b013e3181c80aa4.

DOI:10.1097/MPH.0b013e3181c80aa4

PMID:20168249

Abstract

BACKGROUND

Non-Hodgkin lymphomas of the breast are uncommon, which represent less than 1% of all breast malignancies and predominantly are of B-cell origin.

OBSERVATION

In this report, a rare case of anaplastic lymphoma kinase (ALK)-positive anaplastic large T-cell lymphoma in the breast of a 16-year-old female without breast implant is described. The patient presented with a 3-month history of progressive right breast swelling and erythema. Clinically, inflammatory breast carcinoma was highly suspected. A tru-cut needle biopsy of the right breast demonstrated infiltration of tumoral cells around the breast lobules and soft tissue and also in angiolymphatic spaces. The immunohistochemical profile showed positivity for CD30 and ALK and confirmed the diagnosis of ALK-positive anaplastic large T-cell lymphoma of the breast.

CONCLUSION

Anaplastic large T-cell lymphoma of the breast is rare, and can clinically mimic inflammatory breast carcinoma in adolescence.

摘要

背景

乳腺非霍奇金淋巴瘤并不常见，占所有乳腺恶性肿瘤的比例不到1%，且主要起源于B细胞。

观察

在本报告中，描述了1例罕见的间变性淋巴瘤激酶（ALK）阳性间变性大T细胞淋巴瘤，发生于1名16岁未植入乳房假体的女性乳腺。患者有3个月进行性右乳肿胀和红斑病史。临床上，高度怀疑为炎性乳腺癌。右乳粗针穿刺活检显示肿瘤细胞浸润乳腺小叶周围、软组织以及血管淋巴管间隙。免疫组化结果显示CD30和ALK呈阳性，确诊为乳腺ALK阳性间变性大T细胞淋巴瘤。