Institute of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran.
Mol Diagn Ther. 2010 Aug 1;14(4):243-50. doi: 10.1007/BF03256380.
Burkitt lymphoma (BL) is a highly aggressive neoplasm, which frequently affects the ileocecal region in the sporadic form and the jaw in the endemic form; however, the breast is a rare primary site of this tumor. Here we describe a case of primary bilateral breast BL presenting during lactation in a 23-year-old woman. Excisional biopsy of breast masses demonstrated a B-cell lymphoma with a characteristic 'starry sky' pattern highly suggestive of BL. The neoplastic cells strongly expressed CD20 and CD10, and showed proliferative activity as measured by Ki-67. An IGH-MYC gene fusion indicating the presence of a typical Burkitt translocation t(8;14)(q24;q32) in the tumor tissue was detected by fluorescent in situ hybridization. The present case, along with a comprehensive review of the literature, demonstrates that BL of the breast should be considered in the differential diagnosis of lesions of the breast during lactation. Whether hormonal or antigenic factors trigger Burkitt lymphomagenesis in the lactating breast warrants further investigation.
伯基特淋巴瘤（BL）是一种高度侵袭性的肿瘤，在散发形式中常累及回盲部，在地方性形式中常累及颌骨；然而，乳腺是该肿瘤的罕见原发部位。本文描述了一例哺乳期 23 岁女性双侧乳腺原发性 BL 病例。乳腺肿块的切除活检显示为 B 细胞淋巴瘤，具有特征性的“星空”模式，高度提示 BL。肿瘤细胞强烈表达 CD20 和 CD10，并通过 Ki-67 显示增殖活性。荧光原位杂交检测到肿瘤组织中存在指示典型伯基特易位 t(8;14)(q24;q32)的 IGH-MYC 基因融合。本病例以及对文献的全面回顾表明，哺乳期乳腺 BL 应在哺乳期乳腺病变的鉴别诊断中考虑。哺乳期乳腺中伯基特淋巴瘤的发生是否与激素或抗原因素有关，值得进一步研究。
