无黄斑增厚的囊样黄斑水肿：一项回顾性光学相干断层扫描研究。

Cystoid macular edema without macular thickening: a retrospective optical coherence tomographic study.

机构信息

New England Eye Center, Tufts University School of Medicine, Boston, Massachusetts 02116, USA.

出版信息

Retina. 2010 Jun;30(6):917-23. doi: 10.1097/IAE.0b013e3181cbd9e5.

DOI:10.1097/IAE.0b013e3181cbd9e5

PMID:20168270

Abstract

BACKGROUND

This is a retrospective observational case series of 37 eyes of 32 patients meeting the inclusion criteria intended to describe the appearance, prevalence, and associated risk factors for cystoid macular edema in eyes with normal foveal thickness and contour as determined by optical coherence tomography (OCT).

METHODS

A retrospective review of all patients with macular disease who underwent OCT evaluation at the New England Eye Center from January to March 2007 and met the study inclusion criteria was performed. Optical coherence tomography scans were evaluated for the presence of intraretinal cystic fluid or cystoid macular edema but with normal retinal thickness and foveal contour. Retinal thickness and contour were evaluated using OCT mapping software. The main outcome measures were as follows: OCT-defined entity based on the presence of cystoid spaces within the fovea, "normal" foveal thickness (<252 microm), normal foveal contour, and best-corrected visual acuity on the date of examination.

RESULTS

Thirty-seven eyes of 32 patients were determined to have cystoid macular edema with normal foveal thickness and contour on OCT. The overall prevalence within our patient population was 4.9%. Mean foveal thickness (standard deviation) for these patients was 201.4 microm (28.9) compared with normal mean foveal thickness (standard deviation) of 212 microm (20.0). Of the 32 patients, 17 (53.1%) had a primary diagnosis of age-related macular degeneration. The mean visual acuity (Snellen; logarithm of the minimum angle of resolution) was 20/80 (0.60).

CONCLUSION

Cystoid macular edema in the setting of normal foveal thickness and contour as determined by OCT has not been extensively described. This entity is not pathognomonic of a single diagnosis and can occur in the setting of several disparate diagnoses as seen in our cohort. Chief among these were age-related macular degeneration and diabetic retinopathy. Acute postcataract cystoid macular edema was absent.

摘要

背景

这是一项回顾性观察性病例系列研究，共纳入 32 例患者的 37 只眼，这些眼的光学相干断层扫描（OCT）显示黄斑中心凹正常厚度和形态，但存在局灶性视网膜内液性腔或囊样黄斑水肿。

方法

对 2007 年 1 月至 3 月在新英格兰眼中心接受 OCT 检查且符合研究纳入标准的所有黄斑疾病患者进行回顾性分析。OCT 评估存在局灶性视网膜内液性腔或囊样黄斑水肿，但视网膜厚度和黄斑中心凹形态正常。使用 OCT 绘图软件评估视网膜厚度和形态。主要观察指标：基于 OCT 定义的存在于黄斑中心凹的囊样间隙的实体、“正常”黄斑中心凹厚度（<252μm）、正常黄斑中心凹形态和检查当日最佳矫正视力。

结果

37 只眼 OCT 显示存在局灶性视网膜内液性腔或囊样黄斑水肿，但黄斑中心凹厚度正常。在我们的患者人群中，这种情况的总患病率为 4.9%。这些患者的平均黄斑中心凹厚度（标准差）为 201.4μm（28.9），而正常黄斑中心凹厚度（标准差）为 212μm（20.0）。32 例患者中，17 例（53.1%）有年龄相关性黄斑变性的主要诊断。平均视力（Snellen；最小角分辨率对数）为 20/80（0.60）。