类二十烷酸和癌症。
Eicosanoids and cancer.
机构信息
Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA.
出版信息
Nat Rev Cancer. 2010 Mar;10(3):181-93. doi: 10.1038/nrc2809. Epub 2010 Feb 19.
Abstract
Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer. This Review highlights our understanding of the intricate roles of eicosanoids in epithelial-derived tumours and their microenvironment. The knowledge of how these lipids orchestrate the complex interactions between transformed epithelial cells and the surrounding stromal cells is crucial for understanding tumour evolution, progression and metastasis. Understanding the molecular mechanisms underlying the role of prostaglandins and other eicosanoids in cancer progression will help to develop more effective cancer chemopreventive and/or therapeutic agents.
摘要
类二十烷酸，包括前列腺素和白三烯，是具有生物活性的脂类，涉及多种病理过程，如炎症和癌症。这篇综述强调了我们对类二十烷酸在上皮源性肿瘤及其微环境中的复杂作用的理解。了解这些脂质如何协调转化上皮细胞与周围基质细胞之间的复杂相互作用，对于理解肿瘤的演化、进展和转移至关重要。了解前列腺素和其他类二十烷酸在癌症进展中的作用的分子机制将有助于开发更有效的癌症化学预防和/或治疗药物。
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