血小板反应蛋白-1 相互作用调节与癌症相关炎症中的类花生酸代谢和信号转导。
Thrombospondin-1 interactions regulate eicosanoid metabolism and signaling in cancer-related inflammation.
机构信息
Department of Surgery, Wake Forest School of Medicine, Winston-Salem, NC, 27157, USA.
Department of Physiology & Pharmacology, Wake Forest University Health Sciences, Bethesda, MD, 20892, USA.
出版信息
Cancer Metastasis Rev. 2018 Sep;37(2-3):469-476. doi: 10.1007/s10555-018-9737-x.
Abstract
The metabolism of arachidonic acid and other polyunsaturated fatty acids produces eicosanoids, a family of biologically active lipids that are implicated in homeostasis and in several pathologies that involve inflammation. Inflammatory processes mediated by eicosanoids promote carcinogenesis by exerting direct effects on cancer cells and by affecting the tumor microenvironment. Therefore, understanding how eicosanoids mediate cancer progression may lead to better approaches and chemopreventive strategies for the treatment of cancer. The matricellular protein thrombospondin-1 is involved in processes that profoundly regulate inflammatory pathways that contribute to carcinogenesis and metastatic spread. This review focuses on interactions of thrombospondin-1 and eicosanoids in the microenvironment that promote carcinogenesis and how the microenvironment can be targeted for cancer prevention to increase curative responses of cancer patients.
摘要
花生四烯酸和其他多不饱和脂肪酸的代谢产生了二十烷类物质，这是一类生物活性脂质，与内稳态和涉及炎症的几种病理学有关。二十烷类物质介导的炎症过程通过直接作用于癌细胞和影响肿瘤微环境来促进癌症发生。因此，了解二十烷类物质如何介导癌症进展可能会为癌症的治疗带来更好的方法和化学预防策略。细胞外基质蛋白血小板反应蛋白-1 参与了深度调节炎症途径的过程，这些途径有助于癌症发生和转移扩散。这篇综述重点介绍了血小板反应蛋白-1 和二十烷类物质在促进癌症发生的微环境中的相互作用，以及如何针对微环境进行癌症预防，以增加癌症患者的治愈反应。
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