诱导多能干细胞：通往新药的途径。疾病建模、药物发现和再生治疗的催化剂。
Induced pluripotent stem cells: paths to new medicines. A catalyst for disease modelling, drug discovery and regenerative therapy.
机构信息
School of Medicine, University of California, Davis, USA.
出版信息
EMBO Rep. 2010 Mar;11(3):161-5. doi: 10.1038/embor.2010.15. Epub 2010 Feb 19.
Abstract
The invention of iPSC in 2006 has been heralded as a major breakthrough. Wenbin Deng explains the enormous potential of these cells for research into human diseases and development, and discusses the technical and regulatory hurdles to be overcome for their therapeutic use.
摘要
2006 年诱导多能干细胞的发明被视为一项重大突破。邓稳斌解释了这些细胞在人类疾病研究和开发方面的巨大潜力，并讨论了为实现其治疗用途而需要克服的技术和监管障碍。
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Genome integrity: linking pluripotency and tumorgenicity.基因组完整性：连接多能性与致瘤性。
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Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs.利用患者特异性诱导多能干细胞对家族性自主神经功能异常的发病机制及治疗进行建模。
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Adult mice generated from induced pluripotent stem cells.由诱导多能干细胞产生的成年小鼠。
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iPS cells produce viable mice through tetraploid complementation.诱导多能干细胞通过四倍体补偿产生存活的小鼠。
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iPS cells can support full-term development of tetraploid blastocyst-complemented embryos.诱导多能干细胞可支持四倍体囊胚互补胚胎的足月发育。
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