利用力学生物学改善干细胞治疗
Improving Stem Cell Therapeutics with Mechanobiology.
作者信息
Shin Jae-Won, Mooney David J
机构信息
School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
School of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02138, USA.
出版信息
Cell Stem Cell. 2016 Jan 7;18(1):16-9. doi: 10.1016/j.stem.2015.12.007.
Abstract
In recent years, it has become clear that mechanical cues play an integral role in maintaining stem cell functions. Here we discuss how integrating physical approaches and engineering principles in stem cell biology, including culture systems, preclinical models, and functional assessment, may improve clinical application in regenerative medicine.
摘要
近年来，越来越明显的是，机械信号在维持干细胞功能中起着不可或缺的作用。在此，我们讨论如何将物理方法和工程原理整合到干细胞生物学中，包括培养系统、临床前模型和功能评估，这可能会改善再生医学的临床应用。
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