Lenox R H, Meyerhoff J L, Gandhi O P, Wray H L
J Cyclic Nucleotide Res. 1977 Oct;3(5):367-79.
Techniques of in-vivo microwave irradiation to inactivate brain enzymes in rats were varied as to exposure configuration and output power. The rate at which metabolism was stopped was studied in various regions of the rat brain, using changes in levels of cyclic AMP and phosphodiesterase activity. Exposure times required to obtain stabilized levels of cyclic AMP varied in different brain regions, i.e., hypothalamus, cortex and cerebellum. Levels of cyclic AMP in selective regions of the brain decreased as more rapid inactivation was achieved. The authors identify important sources of variability of present microwave inactivation systems and the need for improved control of signficant microwave parameters.
对大鼠进行体内微波辐射以灭活脑酶的技术，在暴露配置和输出功率方面有所不同。利用环磷酸腺苷（cAMP）水平和磷酸二酯酶活性的变化，研究了大鼠脑不同区域代谢停止的速率。在不同脑区（即下丘脑、皮层和小脑）中，达到cAMP稳定水平所需的暴露时间各不相同。随着更快速的失活实现，脑选择性区域的cAMP水平下降。作者确定了当前微波失活系统变异性的重要来源以及改进对重要微波参数控制的必要性。
