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丹参对重症急性胰腺炎或阻塞性黄疸大鼠肠系膜淋巴结的影响。

Influence of Salvia miltiorrhizae on the mesenteric lymph node of rats with severe acute pancreatitis or obstructive jaundice.

机构信息

Department of General Surgery, Hangzhou First People's Hospital, Zhejiang Province, Hangzhou 310006, China.

出版信息

Mediators Inflamm. 2009;2009:675195. doi: 10.1155/2009/675195. Epub 2010 Feb 15.

DOI:10.1155/2009/675195
PMID:20169004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2822241/
Abstract

OBJECTIVE

To observe the effect of salvia miltiorrhizae injection on inflammatory mediator levels and mesenteric lymph nodes in severe acute pancreatitis (SAP) and obstructive jaundice (OJ) rats and explore the protective mechanism of salvia miltiorrhizae on the lymph nodes of these rats.

METHODS

A total of 288 rats were used in SAP-associated and OJ-associated experiments. The rats were randomly divided into sham-operated group, model control group, and treated group. At various time points after operation, the pathological changes in mesenteric lymph nodes of rats in each group were observed, respectively.

RESULTS

The pathological severity scores in lymph nodes of SAP rats in treated group were significantly lower than those in model control group (P < .05) while the pathological changes in lymph nodes of OJ rats in treated group also showed varying degrees of mitigation.

CONCLUSION

Salvia miltiorrhizae can exert protective effects on the lymph nodes of SAP or OJ rats via a mechanism that is associated with reducing the contents of inflammatory mediators in blood.

摘要

目的

观察丹参注射液对重症急性胰腺炎（SAP）和阻塞性黄疸（OJ）大鼠炎症介质水平和肠系膜淋巴结的影响，探讨丹参对大鼠淋巴结的保护作用机制。

方法

将 288 只大鼠用于 SAP 相关和 OJ 相关实验。大鼠随机分为假手术组、模型对照组和治疗组。在手术后的不同时间点，观察每组大鼠肠系膜淋巴结的病理变化。

结果

治疗组 SAP 大鼠淋巴结的病理严重程度评分明显低于模型对照组（P <.05），而治疗组 OJ 大鼠淋巴结的病理变化也呈现出不同程度的缓解。

结论

丹参通过降低血液中炎症介质的含量，对 SAP 或 OJ 大鼠的淋巴结发挥保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/2822241/74539e4b301a/MI2009-675195.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/2822241/74539e4b301a/MI2009-675195.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7345/2822241/74539e4b301a/MI2009-675195.001.jpg

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本文引用的文献

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Mediators Inflamm. 2009;2009:186136. doi: 10.1155/2009/186136. Epub 2009 Nov 16.
2
Protective effects of Salvia miltiorrhizae on multiple organs of rats with obstructive jaundice.丹参对梗阻性黄疸大鼠多器官的保护作用。
Mediators Inflamm. 2009;2009:602935. doi: 10.1155/2009/602935. Epub 2009 Aug 6.
3
Effect of salvia miltiorrhizae on pulmonary apoptosis of rats with severe acute pancreatitis or obstructive jaundice.
丹参对重症急性胰腺炎或阻塞性黄疸大鼠肺细胞凋亡的影响。
Inflammation. 2009 Oct;32(5):287-95. doi: 10.1007/s10753-009-9132-4.
4
Effects of Salvia miltiorrhizae on ICAM-1, TLR4, NF-kappaB and Bax proteins expression in multiple organs of rats with severe acute pancreatitis or obstructive jaundice.丹参对重症急性胰腺炎或梗阻性黄疸大鼠多器官中细胞间黏附分子-1（ICAM-1）、Toll样受体4（TLR4）、核因子κB（NF-κB）及Bax蛋白表达的影响
Inflammation. 2009 Aug;32(4):218-32. doi: 10.1007/s10753-009-9124-4.
5
Effect of salvia miltiorrhizae on the expressions of TLR4 protein in the liver of rats with SAP or OJ.丹参对重症急性胰腺炎或梗阻性黄疸大鼠肝脏中TLR4蛋白表达的影响。
Inflammation. 2009 Jun;32(3):151-62. doi: 10.1007/s10753-009-9114-6.
6
Protective effects of Salvia miltiorrhizae on the hearts of rats with severe acute pancreatits or obstructive jaundice.丹参对重症急性胰腺炎或梗阻性黄疸大鼠心脏的保护作用。
J Zhejiang Univ Sci B. 2009 Mar;10(3):193-202. doi: 10.1631/jzus.B0820179.
7
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