Idigbe Emmanuel Oni, Audu Rosemary A, Iroha Edna O, Akinsulie Adebola O, Temiye Edamisan Olusoji, Ezeaka Veronica C, Adetifa Ifedayo M O, Musa Adesola Z, Onyewuche Joseph, Ikondu Sylvester U
Human Virology Laboratory, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
Int J Pediatr. 2010;2010:474380. doi: 10.1155/2010/474380. Epub 2010 Feb 11.
Population studies showed that there are differences in T-lymphocytes subpopulation of normal children in different regions, and reference values in an area might be different from another. This study compared the values in our population with CDC and WHO reference values. Blood samples from 279 healthy, HIV-negative children <12 years of age were analysed for complete blood count, CD3+, CD4+, CD8+ counts and percentages. Except for CD8%, mean values for all parameters measured significantly decreased with age. CD4+ counts were higher in females than males, P < .05. Using the WHO criteria, 15.9% of subjects had low total lymphocyte count and 20.6% had low CD4 count. Children <3 years had median CD4% lower than WHO normal values. Our median CD4+ counts correlated with CDC values. Values used by WHO in infants are higher than ours. We suggest that our children be assessed using CDC reference values which correlate with ours.
人群研究表明，不同地区正常儿童的T淋巴细胞亚群存在差异，一个地区的参考值可能与另一个地区不同。本研究将我们人群中的数值与美国疾病控制与预防中心（CDC）和世界卫生组织（WHO）的参考值进行了比较。对279名12岁以下健康的HIV阴性儿童的血样进行了全血细胞计数、CD3+、CD4+、CD8+计数及百分比分析。除CD8%外，所有测量参数的平均值均随年龄显著降低。女性的CD4+计数高于男性，P < .05。根据WHO标准，15.9%的受试者总淋巴细胞计数低，20.6%的受试者CD4计数低。3岁以下儿童的CD4%中位数低于WHO正常数值。我们的CD4+计数中位数与CDC数值相关。WHO用于婴儿的数值高于我们的。我们建议使用与我们的数值相关的CDC参考值来评估我们的儿童。
