Laboratory of Neuroscience, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Arch Womens Ment Health. 2010 Jun;13(3):285-9. doi: 10.1007/s00737-010-0146-6. Epub 2010 Feb 19.
Postpartum depression disorder (PPD) is a severe illness affecting around 15% of deliveries. Several evidences suggest that PPD is, at least, partially genetic determined. The gene encoding BDNF is a strong candidate for pathogenesis of PPD since that it has been observed decrease of serum BDNF in patients suffering from PPD. The gene encoding BDNF has a polymorphism (Val66Met) that alters the regulated protein secretion; the methionine variant being associated with insufficient secretion compared with the Valine variant. We hypothesized that BDNF gene Val66Met polymorphism could be associated with PPD. We assessed 227 subjects randomly selected who had delivery at a maternity hospital using EPDS. Differences in genotype frequency were calculated by chi (2) test. Logistic Regression Analyses was performed to verify the existence of interaction between biological, psychiatric and environmental variables and PPD. Difference between groups was tested with Student's t test. Tests were two-tailed and results significant when p < or = 0.05. No difference in BDNF genotype distribution was observed between the depressed and non-depressed women. Educational level, stress during pregnancy, bipolar disorder and anxiety was strongly associated with PPD. We were not able to show an association between BDNF polymorphisms and PPD. Further studies are necessary to both of confirm our results and improve validity of PPD diagnosis.
产后抑郁症（PPD）是一种严重的疾病，影响约 15%的分娩。有几项证据表明，PPD 至少部分是由遗传决定的。编码 BDNF 的基因是 PPD 发病机制的一个强有力的候选基因，因为已经观察到患有 PPD 的患者血清 BDNF 减少。BDNF 基因有一个多态性（Val66Met），改变了受调控的蛋白质分泌；与 Valine 变体相比，蛋氨酸变体与分泌不足有关。我们假设 BDNF 基因 Val66Met 多态性与 PPD 有关。我们使用 EPDS 评估了在一家妇产科医院分娩的 227 名随机选择的受试者。通过卡方检验（chi(2) test）计算基因型频率的差异。使用逻辑回归分析来验证生物学、精神科和环境变量与 PPD 之间是否存在相互作用。使用 Student's t 检验检验组间差异。检验为双侧检验，当 p<0.05 时结果具有统计学意义。在抑郁和非抑郁女性之间，BDNF 基因型分布没有差异。教育程度、怀孕期间的压力、双相情感障碍和焦虑与 PPD 密切相关。我们未能显示 BDNF 多态性与 PPD 之间存在关联。需要进一步的研究来确认我们的结果，并提高 PPD 诊断的有效性。
