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生命是什么?在涌现复杂性的背景下定义生命。

What is life? Defining life in the context of emergent complexity.

机构信息

Department of Chemistry & Biochemistry, California State University Fullerton, Fullerton, CA 92835-6866, USA.

出版信息

Orig Life Evol Biosph. 2010 Apr;40(2):221-9. doi: 10.1007/s11084-010-9203-4. Epub 2010 Feb 19.

Abstract

Erwin Schrödinger defined life not only as a "self-reproducing" aperiodic crystal of DNA coding for proteins but within the context of living entities increasing their order by dissipating matter/energy gradients to maintain themselves away from equilibirium. Since then most definitions of life have focused on the former. But living cells do more than replicate their DNA. Cells also have membrane barriers across which metabolites must move, via which energy transduction as well as information processing occurs, and within which metabolic transformation occurs. An approach of complex systems dynamics, including nonequilibrium thermodynamics, may provide a more robust approach for defining life than a "naked replicator" at the origin of life. The crucial issue becomes the process of emergence of life from pre-biotic chemistry, concomitant with the emergence of function, information, and semiosis. Living entities can be viewed as bounded, informed autocatalytic cycles feeding off matter/energy gradients, exhibiting agency, capable of growth, reproduction, and evolution. Understanding how life might have emerged should sharpen our definition of what life is.

摘要

埃尔温·薛定谔不仅将生命定义为一种“自我复制”的 DNA 非周期性晶体,编码蛋白质,而且还将其定义为一种通过耗散物质/能量梯度来增加自身有序性的生物体,从而使其远离平衡状态。从那时起,大多数生命的定义都集中在前一种定义上。但是,活细胞所做的不仅仅是复制它们的 DNA。细胞还有膜屏障,代谢物必须通过这些屏障移动,能量转导和信息处理也发生在这些屏障中,代谢转化也发生在这些屏障中。复杂系统动力学的方法,包括非平衡热力学,可能为生命的定义提供比生命起源时的“赤裸裸的复制子”更强大的方法。关键问题是生命从前生物化学中出现的过程,同时出现的还有功能、信息和符号。生物体可以被看作是有界的、有信息的自催化循环,以物质/能量梯度为食,表现出能动性,能够生长、繁殖和进化。了解生命是如何出现的,应该能使我们更清楚地定义生命是什么。

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