Orto-aminoazotoluen induces the expression of the p53 gene in inbred strains of mice susceptible and resistant to hepatocarcinogenesis.

作者信息

Timofeeva O A, Eremeev A V, Goloshchapov A N, Ilnitskaya S I, Merculova T I, Kaledin V I, Setkov N A

机构信息

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent'eva 8, Novosibirsk 630090, Russia.

出版信息

Dokl Biol Sci. 2009 Nov-Dec;429:579-82. doi: 10.1134/s0012496609060271.

DOI:10.1134/s0012496609060271

PMID:20170078

Abstract

摘要

相似文献

Orto-aminoazotoluen induces the expression of the p53 gene in inbred strains of mice susceptible and resistant to hepatocarcinogenesis.

Dokl Biol Sci. 2009 Nov-Dec;429:579-82. doi: 10.1134/s0012496609060271.

Effects of o-aminoazotoluene on liver regeneration and p53 activation in mice susceptible and resistant to hepatocarcinogenesis.

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[Ratio of spontaneous and o-aminoazotoluene-induced hepatocarcinogenesis in mice].

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[Activity and inducibility of cytochrome p-450-1A in the liver of mice with different sensitivity to hepatocarcinogenic effect of o-aminoazotoluene].

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Promoting effect of o-aminoazotoluene on hepatocarcinogenesis is accompanied by the increase in inflammatory and proliferative processes in liver tissue and decrease in the concentration of free thyroxin in the blood.

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[Characteristics of alpha-fetoprotein synthesis in the early stages of hepatic carcinogenesis in mice with a various sensitivity to ortho-aminoazotoluene].[对邻氨基偶氮甲苯具有不同敏感性的小鼠肝癌发生早期甲胎蛋白合成的特征]

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O-aminoazotoluene suppresses hepatocyte proliferation in inbred mice susceptible to hepatocarcinogenesis.

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[Different sensitivity of inbred mice to hepatocarcinogen ortho-aminoazotoluene may be due to differences in the negative control mechanisms of hepatocyte proliferation].

Tsitologiia. 2004;46(4):301-11.

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[Transplancental effect of ortho-aminoazotoluene on organ cultures of embryonal liver from mouse lines C57BL and CBA].

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本文引用的文献

Hepatocellular carcinoma: overcoming challenges in disease management.肝细胞癌：克服疾病管理中的挑战

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Hepatocellular carcinoma as a complex polygenic disease. Interpretive analysis of recent developments on genetic predisposition.肝细胞癌作为一种复杂的多基因疾病。对遗传易感性最新进展的解释性分析。

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The mechanisms of endogenous control of hepatocyte proliferation are different in mice of two inbred strains (BALB/c and AKR).

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Genotoxicity of o-aminoazotoluene (AAT) determined by the Ames test, the in vitro chromosomal aberration test, and the transgenic mouse gene mutation assay.通过艾姆斯试验、体外染色体畸变试验和转基因小鼠基因突变试验测定邻氨基偶氮甲苯（AAT）的遗传毒性。

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Expression of CYP1A in liver of A/Sn and CC57BR mice differing in sensitivity to hepatocarcinogenesis induced by o-aminoazotoluene.

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p53 protein expression by hepatocarcinogens in the rat liver and its potential role in mitoinhibition of normal hepatocytes as a mechanism of hepatic tumour promotion.

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p53, the cellular gatekeeper for growth and division.p53，细胞生长和分裂的守门人。

Cell. 1997 Feb 7;88(3):323-31. doi: 10.1016/s0092-8674(00)81871-1.

Inexpensive SDS/phenol method for RNA extraction from tissues.用于从组织中提取RNA的廉价十二烷基硫酸钠/苯酚法。

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[Different predisposition to the development of spontaneous and induced liver tumors in mice of different strains and their hybrids].

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