Jackson B A, Schwane J A, Starcher B C
Department of Health and Kinesiology, University of Texas, Tyler 75701.
Med Sci Sports Exerc. 1991 Feb;23(2):171-6.
The purpose was to determine the effects of selected regimens of ultrasound therapy on the rates of repair of injured Achilles tendons of rats. Specific dependent variables examined were tendon breaking strength and rate of collagen formation. A puncture technique was used to induce injuries to both Achilles tendons of rats. Continuous ultrasound was administered to the left tendon for 4 min per treatment session at an intensity of 1.5 W.cm-2. Rats were sacrificed 2, 5, 9, 15, and 21 d following injury for measurement of tendon breaking strength and 3 and 5 d postinjury for analysis of collagen synthesis. Breaking strength was defined as the minimum force required to completely rupture the tendon. Collagen synthesis was indicated by the conversion of labeled proline to hydroxyproline. The breaking strengths of the treated tendons were significantly greater than strengths of the untreated tendons 5, 9, 15, and 21 d postinjury. Collagen synthesis was increased in the treated tendons compared with the untreated tendons 5 d postinjury. The results indicate that ultrasound treatment increases the rate of repair of injured Achilles tendons of rats. The results are also consistent with an association between increased collagen synthesis and greater breaking strength during tendon repair.
目的是确定所选超声治疗方案对大鼠跟腱损伤修复速度的影响。所检测的特定因变量为肌腱断裂强度和胶原蛋白形成速率。采用穿刺技术对大鼠的双侧跟腱造成损伤。对左侧肌腱每次治疗持续给予4分钟的连续超声，强度为1.5W/cm²。在损伤后2、5、9、15和21天处死大鼠以测量肌腱断裂强度，并在损伤后3天和5天处死大鼠以分析胶原蛋白合成。断裂强度定义为使肌腱完全断裂所需的最小力。胶原蛋白合成通过标记脯氨酸转化为羟脯氨酸来表示。在损伤后5、9、15和21天，治疗组肌腱的断裂强度显著高于未治疗组肌腱。与未治疗组肌腱相比，治疗组肌腱在损伤后5天胶原蛋白合成增加。结果表明，超声治疗可提高大鼠损伤跟腱的修复速度。这些结果还与肌腱修复过程中胶原蛋白合成增加和更大的断裂强度之间的关联相一致。
