Department of Medical Rehabilitation, Oulu University Hospital, Institute of Health Sciences, University of Oulu, Oulu, Finland.
Scand J Clin Lab Invest. 2010 Apr;70(2):75-9. doi: 10.3109/00365510903410548.
Abstract Background. High levels of high-sensitivity C-reactive protein (hs-CRP) are associated with depressed mood, but the causal relationships are not known. Therefore, we examined the relationships between hs-CRP and incident depressed mood among the elderly. Methods. Altogether 764 (69%) individuals out of a representative sample of subjects aged 70 years or older (N = 1113) were screened with the Short Zung Self Rating Depression Scale (SZSRDS), and serum hs-CRP determinations were done at the same time. After a two-and-a-half-year follow-up, the SZSRDS examinations were repeated among those who were free of depressed mood (SZSRDS score >or=28 or use of an anti-depressant drug) at the baseline (N = 404). Analysis of covariance (ANCOVA) and logistic regression were used to analyse the relationship between the baseline hs-CRP (<1, 1 < 3, 3 <10 mg/L) and the follow-up SZSRDS scores (10-40) and depressed mood. Results. Baseline hs-CRP was not associated with an increasing trend in SZSRDS scores and depressed mood in the total study population, but there was a significant gender interaction. Among the men, elevated hs-CRP was associated with an increasing trend in the SZSRDS score and depressed mood. Conclusions. High hs-CRP predicts a higher incident SZSRDS score and depressed mood among older men, suggesting a possible inflammatory etiology for depression.
高水平的高敏 C 反应蛋白（hs-CRP）与抑郁情绪有关，但因果关系尚不清楚。因此，我们研究了 hs-CRP 与老年人抑郁情绪发生的关系。方法：从年龄在 70 岁及以上的代表性样本中（N=1113），共筛选出 764 人（69%）接受了短版 Zung 自评抑郁量表（SZSRDS）评估，同时检测了血清 hs-CRP。在 2.5 年的随访后，对基线时无抑郁情绪（SZSRDS 评分≥28 或使用抗抑郁药）的 404 人（N=404）重复进行了 SZSRDS 检查。采用协方差分析（ANCOVA）和逻辑回归分析了基线 hs-CRP（＜1、1＜3、3＜10 mg/L）与随访时 SZSRDS 评分（10-40）和抑郁情绪之间的关系。结果：基线 hs-CRP 与研究人群的 SZSRDS 评分和抑郁情绪的增加趋势无关，但存在显著的性别交互作用。在男性中，hs-CRP 升高与 SZSRDS 评分和抑郁情绪的增加趋势有关。结论：hs-CRP 升高预测老年男性中 SZSRDS 评分和抑郁情绪的发生率更高，提示抑郁可能存在炎症病因。
