Zhang Lin, Li Jin-Long, Zhang Li-Li, Guo Lei-Lei, Li Hong, Li Dan
Department of Community Nursing, School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning Province Department of Occupational and Environmental Health, Key Laboratory of Occupational Health and Safety for Coal Industry in Hebei Province, School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province Department of Surgery, Third Affiliated Hospital of Jinzhou Medical University Experimental Center for Nursing, School of Nursing, Jinzhou Medical University, Jinzhou, Liaoning Province, P.R. China.
Medicine (Baltimore). 2018 Sep;97(38):e12352. doi: 10.1097/MD.0000000000012352.
The depressive symptoms have been associated with increased disabilities, and the depressive symptoms-related elevation of high C-reactive protein (CRP) has been proposed as a possible mechanism. We examined the relations between CRP and depressive symptoms among the middle-aged and elderly in China.A longitudinal sample of the middle-aged and elderly (4404 men and 5055 women) who were interviewed in the 2011 China Health and Retirement Longitudinal Study was used. A multivariate logistic regression analysis was used to examine the effects of sociodemographic characteristics, lifestyle, activity status, physical exercise, systolic blood pressure, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, body mass index (BMI), and CRP levels on depressive symptoms.The mean age in the study was 60.26 years [standard deviation (SD) ± 9.25; 46.56% men]. The mean CPR level was 2.79 mg/L (range, 0.01-178.10; SD ± 7.80). Depression scores ranged from 0 to 30 with a mean 8.65 (SD ± 6.33). The prevalence of depressive symptoms was 38.49% in the total population, 31.04% in men and 44.99% in men. Compared with baseline CRP levels (≤1.00 mg/L), the depressive symptoms are only weakly correlated with CRP levels among women [CRP 1.01-3.00 mg/L: odds ratio (OR) = 0.85, 95% confidence interval (CI) = 0.73-0.98; CRP 3.01-10.00 mg/L: OR = 1.25, 95% CI = 1.03-1.51; CRP >10 mg/L: OR = 1.41, 95% CI = 1.06-1.88]. After adjusting for age, education, marital status, hukou, residence, cigarette smoking, alcohol drinking, eating meals, activity status, major accidental injury, diseases, health status, physical exercise, systolic blood pressure, LDL, HDL, triglycerides, and BMI, depressive symptoms were not associated with subsequent high CPR levels among the middle-aged and elderly (CRP 1.01-3.00 mg/L: OR = 0.93, 95% CI = 0.83-1.03; CRP 3.01-10.00 mg/L: OR = 0.95, 95% CI = 0.82-1.10; CRP >10 mg/l: OR = 1.11, 95% CI = 0.88-1.39).Our data do not support an association between CRP and depressive symptoms in both middle-aged and elderly men and women among china.
抑郁症状与残疾增加有关，高C反应蛋白（CRP）相关的抑郁症状升高被认为是一种可能的机制。我们研究了中国中老年人中CRP与抑郁症状之间的关系。使用了2011年中国健康与养老追踪调查中接受访谈的中老年人纵向样本（4404名男性和5055名女性）。采用多因素逻辑回归分析来研究社会人口学特征、生活方式、活动状态、体育锻炼、收缩压、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、甘油三酯、体重指数（BMI）和CRP水平对抑郁症状的影响。研究的平均年龄为60.26岁[标准差（SD）±9.25；男性占46.56%]。平均CPR水平为2.79mg/L（范围0.01 - 178.10；SD±7.80）。抑郁评分范围为0至30，平均为8.65（SD±6.33）。抑郁症状在总人口中的患病率为38.49%，男性为31.04%，女性为44.99%。与基线CRP水平（≤1.00mg/L）相比，女性中抑郁症状与CRP水平仅呈弱相关[CRP 1.01 - 3.00mg/L：比值比（OR）=0.85，95%置信区间（CI）=0.73 - 0.98；CRP 3.01 - 10.00mg/L：OR = 1.25，95% CI = 1.03 - 1.51；CRP >10mg/L：OR = 1.41，95% CI = 1.06 - 1.88]。在调整年龄、教育程度、婚姻状况、户口、居住地、吸烟、饮酒、用餐、活动状态、重大意外伤害、疾病、健康状况、体育锻炼、收缩压、LDL、HDL、甘油三酯和BMI后，中老年人中抑郁症状与随后的高CPR水平无关（CRP 1.01 - 3.00mg/L：OR = 0.93，95% CI = 0.83 - 1.03；CRP 3.01 - 10.00mg/L：OR = 0.95，95% CI = 0.82 - 1.10；CRP >10mg/l：OR = 1.11，95% CI = 0.88 - 1.39）。我们的数据不支持中国中老年男性和女性中CRP与抑郁症状之间存在关联。
