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1964-2003 年间北欧国家唇癌、口腔癌和口咽癌患者的生存趋势,随访至 2006 年底。

Trends in the survival of patients diagnosed with cancers of the lip, oral cavity, and pharynx in the Nordic countries 1964-2003 followed up to the end of 2006.

机构信息

Finnish Cancer Registry, Pieni Roobertinkatu 9, Helsinki, Finland.

出版信息

Acta Oncol. 2010 Jun;49(5):561-77. doi: 10.3109/02841860903575307.

Abstract

BACKGROUND

This is the first comprehensive population-based study on relative survival of lip, oral cavity and pharyngeal cancer in the Nordic countries.

MATERIAL AND METHODS

Relative survival of patients with cancers of the lip, oral cavity, and pharynx diagnosed in the Nordic countries in 1964-2003 and followed up to the end of 2006 was studied and contrasted with trends in incidence and mortality.

RESULTS

There are marked differences in incidence between countries and over time. The stability of the relative survival ratios gives support to the hypothesis that the incidence differences are more likely to be real and not materially affected by differences in definitions and coding. Of particular note are the steep rises in pharyngeal cancer incidence in Denmark in both sexes. Survival has only moderately improved over time and has tended to be slightly higher in females than males.

CONCLUSIONS

Co-morbidity caused by smoking and high alcohol consumption are likely to be partially responsible for differences between countries. Advances in therapy and standards of care are also likely to have played a role in the increasing survival trends.

摘要

背景

这是北欧国家首次针对唇癌、口腔癌和口咽癌相对存活率进行的全面基于人群的研究。

材料与方法

研究了 1964-2003 年间在北欧国家诊断出的唇癌、口腔癌和口咽癌患者的相对存活率,并与发病率和死亡率的趋势进行了对比。

结果

各国之间和随时间推移发病率存在显著差异。相对存活率的稳定性支持了这样一种假设,即发病率差异更有可能是真实的,而不会受到定义和编码差异的实质性影响。特别值得注意的是丹麦男女两性口咽癌发病率的急剧上升。随着时间的推移,生存率仅略有改善,女性生存率略高于男性。

结论

吸烟和大量饮酒引起的合并症可能是造成国家间差异的部分原因。治疗方法的进步和护理标准的提高也可能在生存率上升趋势中发挥了作用。

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