Lubpairee Tarinee, Poh Catherine F, Laronde Denise M, Rosin Miriam P, Zhang Lewei
Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia (BC), Vancouver, Canada.
BC Oral Cancer Prevention Program, BC Cancer Agency, Vancouver, Canada.
J Oncol Res Ther. 2017;3(4). Epub 2017 Sep 25.
1.1.Although oral cancers traditionally occur in people between the age of 50 and 70, there are increasing incidences of this disease in younger and very old people. Objectives: to compare the demographics, habits, clinicopathological features, treatment and outcome of oral cancer in three age groups of patients: Young (≤ 45), Traditional (46 to 75), and Old (> 75).
1.2.Primary oral cancers (393 patients) in a longitudinal study were used.
1.3.Significant differences were noted in ethnicity (fewer Caucasian patients in Young), tobacco habit (more non-smokers in Young), location of cancer (more at tongue for Young and more at low-risk sites for Old) and treatment (more surgery for Young). Compared to Young (univariate analysis), Traditional and Old showed a 3- and 4.5-fold increase in local recurrences respectively; 1.9- and 2.7-fold increase in regional metastasis; 3.1- and 5.4-fold increase in death due to disease; and a 3.4- and 6.6-fold decrease in overall survival. Compared to Young (multivariate analysis), Traditional and Old showed a 2.4- and 3.3-fold increase in local recurrence; 2.7- and 5.4-fold increase in disease-specific survival; and 2.8- and 6.5-fold decrease in overall survival.
1.4.Oral cancer in different age groups showed differing ethnicity, habit, location, treatment and outcome.
1.1. 虽然口腔癌传统上多发生于50至70岁的人群，但该疾病在年轻人和老年人中的发病率正在上升。目的是比较三组患者口腔癌的人口统计学特征、习惯、临床病理特征、治疗方法及预后：年轻组（≤45岁）、传统组（46至75岁）和老年组（>75岁）。
1.2. 使用纵向研究中的原发性口腔癌患者（393例）。
1.3. 在种族（年轻组中白种人患者较少）、吸烟习惯（年轻组中非吸烟者较多）、癌症位置（年轻组中更多发生于舌部，老年组中更多发生于低风险部位）和治疗方法（年轻组中更多采用手术治疗）方面存在显著差异。与年轻组相比（单因素分析），传统组和老年组的局部复发率分别增加了3倍和4.5倍；区域转移率分别增加了1.9倍和2.7倍；疾病致死率分别增加了3.1倍和5.4倍；总生存率分别降低了3.4倍和6.6倍。与年轻组相比（多因素分析），传统组和老年组的局部复发率分别增加了2.4倍和3.3倍；疾病特异性生存率分别增加了2.7倍和5.4倍；总生存率分别降低了2.8倍和6.5倍。
1.4. 不同年龄组的口腔癌在种族、习惯、位置、治疗方法及预后方面存在差异。
