Robert A M, Godeau G, Moati F, Miskulin M
J Med. 1977;8(5):321-32.
Proteases and especially collagenase injected into the lateral brain ventricles of rats are able to increase the permeability of the blood-brain barrier to trypan blue. Treatment of the rats with anthocyanosides of Vaccinium myrtillis diminishes the permeability increasing effect of collagenase and accelerate the recovery of normal permeability. This effect seems to be related to a less effective enzymatic attack on collagen, as hydroxyproline content in the CSF is increased less after collagenase injection in treated animals than in untreated controls.
向大鼠侧脑室注射蛋白酶，尤其是胶原酶，能够增加血脑屏障对锥虫蓝的通透性。用欧洲越橘花青素处理大鼠，可减弱胶原酶对通透性的增强作用，并加速正常通透性的恢复。这种作用似乎与对胶原的酶促攻击效果减弱有关，因为与未处理的对照组相比，经处理的动物在注射胶原酶后，脑脊液中羟脯氨酸含量的增加较少。
