Godeau G, Gavignet C, Groult N, Robert A M
Clin Physiol Biochem. 1987;5(1):15-26.
Intravenously injected collagenase, detectable in brain microvessels by immunological methods, partially degrades the constituents of the vascular wall and so increases the permeability of the blood-brain barrier (BBB). Intravenous administration of collagenase is a model for diseases in which the concentration of endogenous proteases is increased. Peroral treatment of rats with chromocarb diethylamine (CD) significantly reduced the degradation of the vascular wall by intravenous collagenase, as demonstrated by a lesser permeability increase of the BBB, a shorter recovery time, lower hydroxyproline levels in the cerebrospinal fluid and a lesser decrease of the collagen content of the brain capillary basal lamina.
静脉注射胶原酶后，通过免疫方法可在脑微血管中检测到，它会部分降解血管壁成分，从而增加血脑屏障（BBB）的通透性。静脉注射胶原酶是内源性蛋白酶浓度升高的疾病模型。用二乙胺色满卡波（CD）对大鼠进行口服治疗，显著降低了静脉注射胶原酶对血管壁的降解，这表现为血脑屏障通透性增加较少、恢复时间较短、脑脊液中羟脯氨酸水平较低以及脑毛细血管基膜胶原含量降低较少。
