胶原酶对血脑屏障通透性的作用机制。以辣根过氧化物酶作为示踪剂显示内皮细胞胞饮活性增加。
Mechanism of action of collagenase on the blood-brain barrier permeability. Increase of endothelial cell pinocytotic activity as shown with horse-radish peroxidase as a tracer.
作者信息
Godeau G, Robert A M
出版信息
Cell Biol Int Rep. 1979 Dec;3(9):747-51. doi: 10.1016/0309-1651(79)90080-8.
PMID:228873
Abstract
The ultrastructural mechanism of the protease induced blood-brain barrier permeability-increase was studied with horse-radish peroxidase as a tracer. After intravenous injection of collagenase or pronase, a significantly increased number of pinocytotic vesicles was found in brain capillary endothelial cells. alpha-Chymotrypsine did not exert such an action.
摘要
以辣根过氧化物酶为示踪剂，研究了蛋白酶诱导血脑屏障通透性增加的超微结构机制。静脉注射胶原酶或链霉蛋白酶后，脑毛细血管内皮细胞中发现大量吞饮小泡明显增加。α-糜蛋白酶未产生这种作用。
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