解毒内毒素疫苗（J5dLPS/OMP）可保护小鼠免受兔热病弗朗西斯菌 SchuS4 的致死性呼吸道挑战。
Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4.
机构信息
Department of Medicine, Rhode Island Hospital and The Warren Alpert Medical School of Brown University, 55 Claverick Street, Providence, RI 02903, USA.
出版信息
Vaccine. 2010 Apr 1;28(16):2908-15. doi: 10.1016/j.vaccine.2010.01.067. Epub 2010 Feb 17.
Abstract
Francisella tularensis is a category A select agent. J5dLPS/OMP is a novel vaccine construct consisting of detoxified, O-polysaccharide side chain-deficient, lipopolysaccharide non-covalently complexed with the outer membrane protein of N. meningitidis group B. Immunization elicits high-titer polyclonal antibodies specific for the highly-conserved epitopes expressed within the glycolipid core that constitutes gram-negative bacteria (e.g., F. tularensis). Mice immunized intranasally with J5dLPS/OMP exhibited protective immunity to intratracheal challenge with the live vaccine strain, as well as the highly-virulent SchuS4 strain, of F. tularensis. The efficacy of J5dLPS/OMP vaccine suggests its potential utility in immunizing the general population against several different gram-negative select agents concurrently.
摘要
土拉弗朗西斯菌是 A 类选择性制剂。J5dLPS/OMP 是一种新型疫苗构建体，由脱毒的、O-多糖侧链缺失的、与 B 群脑膜炎奈瑟菌的外膜蛋白非共价复合的脂多糖组成。免疫接种会引发针对高度保守表位的高滴度多克隆抗体，这些表位在构成革兰氏阴性菌（例如，土拉弗朗西斯菌）的糖脂核心内表达。经鼻腔免疫接种 J5dLPS/OMP 的小鼠对经气管内挑战活疫苗株以及高度毒力的 SchuS4 株土拉弗朗西斯菌表现出保护免疫力。J5dLPS/OMP 疫苗的功效表明其在同时免疫接种普通人群对抗几种不同的革兰氏阴性选择性制剂方面具有潜在的用途。
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