Health Innovations Research Institute, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia.
Int J Biochem Cell Biol. 2010 Jul;42(7):1072-5. doi: 10.1016/j.biocel.2010.02.007. Epub 2010 Feb 18.
Nogo-A is part of the reticulon family of proteins localized to the myelin and oligodendroglial plasma membranes. Nogo-A specifically initiates signal transduction cascades limiting axonal regrowth following injury and disease in the adult mammalian central nervous system (CNS). Recent novel data support the contention that neuronal Nogo-A plays an important role in regulating cytoskeletal re-organization without the requirement of signaling through its cognate receptor (Nogo receptor). These data, along with the recent findings that the N-terminus of Nogo-A can interact with integrins and that NgR1 interacts with the amyloid precursor protein extracellularly, as well as novel findings showing ubiquitin ligases binding with Nogo-A intracellularly add a layer of complexity to its functional role in the CNS.
Nogo-A 是神经突相关糖蛋白家族的成员之一，定位于髓鞘和少突胶质细胞的质膜上。Nogo-A 特异性地启动信号转导级联反应，限制成年哺乳动物中枢神经系统（CNS）损伤和疾病后的轴突再生。最近的新数据支持这样一种观点，即神经元 Nogo-A 在调节细胞骨架重组方面发挥着重要作用，而不需要通过其同源受体（Nogo 受体）进行信号转导。这些数据，以及最近发现 Nogo-A 的 N 端可以与整合素相互作用，并且 NgR1 与细胞外的淀粉样前体蛋白相互作用，以及新发现显示泛素连接酶与 Nogo-A 细胞内结合，这为其在中枢神经系统中的功能作用增添了一层复杂性。
