三氧化物聚合体：全面文献回顾——第三部分：临床应用、缺点和作用机制。

Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action.

机构信息

Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

J Endod. 2010 Mar;36(3):400-13. doi: 10.1016/j.joen.2009.09.009.

DOI:10.1016/j.joen.2009.09.009

PMID:20171353

Abstract

INTRODUCTION

Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. Two previous publications provided a comprehensive list of articles from November 1993-September 2009 regarding the chemical and physical properties, sealing ability, antibacterial activity, leakage, and biocompatibility of MTA. The purpose of Part III of this literature review is to present a comprehensive list of articles regarding animal studies, clinical applications, drawbacks, and mechanism of action of MTA.

METHODS

A review of the literature was performed by using electronic and hand-searching methods for the clinical applications of MTA in experimental animals and humans as well as its drawbacks and mechanism of action from November 1993-September 2009.

RESULTS

MTA is a promising material for root-end filling, perforation repair, vital pulp therapy, and apical barrier formation for teeth with necrotic pulps and open apexes. Despite the presence of numerous case reports and case series regarding these applications, there are few designed research studies regarding clinical applications of this material. MTA has some known drawbacks such as a long setting time, high cost, and potential of discoloration. Hydroxyapatite crystals form over MTA when it comes in contact with tissue synthetic fluid. This can act as a nidus for the formation of calcified structures after the use of this material in endodontic treatments.

CONCLUSIONS

On the basis of available information, it appears that MTA is the material of choice for some clinical applications. More clinical studies are needed to confirm its efficacy compared with other materials.

摘要

简介

矿化三氧化物凝聚体（MTA）已被推荐用于牙髓学的各种用途。之前有两篇出版物提供了一份全面的文章列表，内容涉及 MTA 的化学和物理性质、密封能力、抗菌活性、渗漏和生物相容性，这些文章的发表时间为 1993 年 11 月至 2009 年 9 月。本文回顾的第三部分旨在提供一份全面的文章列表，内容涉及 MTA 在动物研究、临床应用、缺点和作用机制方面的研究。

方法

通过电子和手工搜索的方法，对 1993 年 11 月至 2009 年 9 月期间 MTA 在实验动物和人类中的临床应用及其缺点和作用机制进行了文献回顾。

结果

MTA 是一种很有前途的根管充填、穿孔修复、活髓治疗和有坏死牙髓和开放根尖的牙齿根尖屏障形成材料。尽管有许多关于这些应用的病例报告和病例系列，但关于这种材料的临床应用的设计研究很少。MTA 存在一些已知的缺点，如凝固时间长、成本高、潜在的变色。当 MTA 与组织合成液接触时，会形成羟基磷灰石晶体。这可以作为该材料在牙髓治疗中使用后形成钙化结构的核心。