University of Sydney Pain Management and Research Institute, Royal North Shore Hospital, St Leonards, NSW, Australia.
Lancet. 2010 Feb 20;375(9715):686-95. doi: 10.1016/S0140-6736(09)61706-2.
For many years, placebos have been defined by their inert content and their use as controls in clinical trials and treatments in clinical practice. Recent research shows that placebo effects are genuine psychobiological events attributable to the overall therapeutic context, and that these effects can be robust in both laboratory and clinical settings. There is also evidence that placebo effects can exist in clinical practice, even if no placebo is given. Further promotion and integration of laboratory and clinical research will allow advances in the ethical use of placebo mechanisms that are inherent in routine clinical care, and encourage the use of treatments that stimulate placebo effects.
多年来，安慰剂一直被定义为其惰性内容及其在临床试验中的对照作用和临床实践中的应用。最近的研究表明，安慰剂效应是真实的心理生物学事件，归因于整体治疗环境，并且这些效应在实验室和临床环境中都很强大。也有证据表明，即使没有使用安慰剂，安慰剂效应也可能存在于临床实践中。进一步促进和整合实验室和临床研究将允许在伦理上使用安慰剂机制方面取得进展，这些机制是常规临床护理固有的，并鼓励使用刺激安慰剂效应的治疗方法。
