Mafla-España Mayra Alejandra, Cauli Omar
Department of Nursing, University of Valencia, 46010 Valencia, Spain.
Frailty Research Organized Group (FROG), University of Valencia, 46010 Valencia, Spain.
Diseases. 2025 Mar 11;13(3):80. doi: 10.3390/diseases13030080.
Symptoms of depression represent a significant burden to patients with breast cancer, not only because of the psychological stress associated with their diagnosis, but also because of the adverse effects of its treatment. We reviewed the clinical trials examining the management of the symptoms of depression in breast cancer patients through different non-pharmacological interventions in different databases (PubMed, Embase, Scopus, and the American Psychological Association). Cognitive behavioural therapy, interpersonal psychotherapy or psychodynamic psychotherapy, as well as acceptance and commitment therapy have been effective in improving symptoms of depression in cancer patients with moderate to severe symptoms. Physical exercise, yoga, mindfulness, and support groups have been shown to benefit patients with mild depressive symptoms. These interventions not only showed positive results in interventions in women with breast cancer in terms of the symptoms of depression, but also highlighted their benefits for comorbid anxiety, stress, and poor sleep quality; moreover, it is suggested that these interventions should be leveraged to manage mental health issues in breast cancer patients. The molecular effects of these interventions, such as the reduction in inflammatory cytokines and cortisol levels, have seldom been reported and need further studies.
抑郁症症状给乳腺癌患者带来了沉重负担，这不仅是因为与癌症诊断相关的心理压力，还因为其治疗产生的不良影响。我们检索了不同数据库（PubMed、Embase、Scopus和美国心理学会数据库）中通过不同非药物干预措施来管理乳腺癌患者抑郁症症状的临床试验。认知行为疗法、人际心理治疗或心理动力心理治疗，以及接受与承诺疗法，对于改善中重度症状的癌症患者的抑郁症状均有效果。体育锻炼、瑜伽、正念减压法和支持小组已被证明对轻度抑郁症状的患者有益。这些干预措施不仅在改善乳腺癌女性患者的抑郁症状方面显示出积极效果，还突出了它们对共病焦虑、压力和睡眠质量差的益处；此外，建议利用这些干预措施来管理乳腺癌患者的心理健康问题。这些干预措施的分子效应，如炎症细胞因子和皮质醇水平的降低，很少被报道，需要进一步研究。
