Martin Daniel C, O'Ryan Felice S, Indresano A Thomas, Bogdanos Pete, Wang Benjamin, Hui Rita L, Lo Joan C
Division of Maxillofacial Surgery, Kaiser Permanente, Oakland Medical Center, Oakland, CA 94611, USA.
J Oral Maxillofac Surg. 2010 Mar;68(3):508-14. doi: 10.1016/j.joms.2009.09.055.
This study examines the pattern of implant failures reported in a large cohort of patients who received oral bisphosphonate therapy.
A total of 8,572 individuals who received oral bisphosphonate drugs returned a dental survey that obtained information pertaining to implant placement and related complications. Among the 589 individuals reporting dental implants, 16 reported implant failures that were verified by dental records. Implant placement, timing of failure, and bisphosphonate duration were ascertained to determine the characteristics of implant loss in the setting of oral bisphosphonate exposure.
Among the 16 patients (all women, aged 70.2 +/- 7.6 yrs) there were 26 implant failures; 8 had failure of 12 implants in the maxilla and 9 had failure of 14 implants in the mandible. Early failure (<or=1 yr after placement) was experienced by 8 patients (8 implants), whereas late failures (>1 yr after placement) occurred in 10 patients (18 implants); 2 patients had both early and late failures.
Overall, few patients reported implant failures. However, among these, there were more late than early failures and a slightly higher proportion of failures in the mandible versus the maxilla. Further studies should investigate the role of chronic bisphosphonate therapy in implant survival and long-term implant osseointegration.
本研究调查了一大群接受口服双膦酸盐治疗的患者中报告的种植体失败模式。
共有8572名接受口服双膦酸盐药物治疗的个体回复了一项牙科调查问卷，该问卷获取了与种植体植入及相关并发症有关的信息。在589名报告有牙种植体的个体中，16名报告的种植体失败情况经牙科记录证实。确定种植体植入情况、失败时间及双膦酸盐治疗持续时间，以确定在口服双膦酸盐情况下种植体丢失的特征。
在这16名患者（均为女性，年龄70.2±7.6岁）中，有26次种植体失败；8名患者上颌的12颗种植体失败，9名患者下颌的14颗种植体失败。8名患者（8颗种植体）出现早期失败（植入后≤1年），而10名患者（18颗种植体）出现晚期失败（植入后>1年）；2名患者同时出现早期和晚期失败。
总体而言，报告种植体失败的患者很少。然而，在这些患者中，晚期失败比早期失败更多，且下颌种植体失败的比例略高于上颌。进一步的研究应调查长期双膦酸盐治疗在种植体存活及种植体长期骨整合中的作用。
