Guobis Zygimantas, Pacauskiene Ingrida, Astramskaite Inesa
Department of Oral and Dental Pathology, Lithuanian University of Health Sciences, Kaunas Lithuania.
Department of Maxillofacial Surgery, Lithuanian University of Health Sciences, Kaunas Lithuania.
J Oral Maxillofac Res. 2016 Sep 9;7(3):e5. doi: 10.5037/jomr.2016.7305. eCollection 2016 Jul-Sep.
To systematically review the influence of systemic diseases or medications used in their treatment on the dental implant therapy success.
The search strategy was implemented on the National Library of Medicine database (MEDLINE) (Ovid) and EMBASE electronic databases between January 2006 and January 2016. Human studies with available English articles analysing the relationship between dental implant therapy success and systemic diseases, such as diabetes mellitus, AIDS/HIV, rheumatoid arthritis, osteoporosis, Crohn's disease, cardiovascular diseases, scleroderma, Sjögren's syndrome, lichen planus, ectodermal dysplasia, post-transplantation status, were included in present review according to the PRISMA guidelines. The review protocol was registered on PROSPERO system with the code CRD42016033662.
Present review included forty one retrospective and prospective follow-up studies, case-control studies, case report series and cohort studies. Despite some limitations this study reveals positive results of implantation in most systemic conditions that should be interpreted with caution. Influence of cardiovascular diseases on the dental implantation success should be explored deeply, because of controversial results and likelihood of comorbidity expressed by a history of cardiovascular diseases and periodontitis. There is only a weak relationship with bone density in osteoporosis and implant failure. All the other diseases did not show significant effect on implantation success.
Recent studies with low strength of evidence and controversy show that systemic diseases may have potential effect on the success of implantation, but further detailed studies are needed to provide these findings.
系统评价全身性疾病或其治疗中使用的药物对牙种植治疗成功率的影响。
检索策略于2006年1月至2016年1月期间在国立医学图书馆数据库（MEDLINE）（Ovid）和EMBASE电子数据库上实施。根据PRISMA指南，本综述纳入了对牙种植治疗成功率与全身性疾病（如糖尿病、艾滋病/艾滋病毒、类风湿性关节炎、骨质疏松症、克罗恩病、心血管疾病、硬皮病、干燥综合征、扁平苔藓、外胚层发育不良、移植后状态）之间关系进行分析的英文文章的人体研究。该综述方案已在PROSPERO系统上注册，注册号为CRD42016033662。
本综述纳入了41项回顾性和前瞻性随访研究、病例对照研究、病例报告系列和队列研究。尽管存在一些局限性，但本研究揭示了在大多数全身性疾病情况下种植的阳性结果，对此应谨慎解读。由于结果存在争议以及心血管疾病病史和牙周炎合并症的可能性，心血管疾病对牙种植成功率的影响应深入探讨。骨质疏松症中骨密度与种植失败之间只有微弱的关系。所有其他疾病对种植成功率均未显示出显著影响。
近期证据强度较低且存在争议的研究表明，全身性疾病可能对种植成功率有潜在影响，但需要进一步详细研究来证实这些发现。
