视神经和视交叉的辐射剂量-体积效应。
Radiation dose-volume effects of optic nerves and chiasm.
机构信息
Department of Radiation Oncology, University of Massachusetts School of Medicine, Worcester, MA 01655, USA.
出版信息
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S28-35. doi: 10.1016/j.ijrobp.2009.07.1753.
Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.
本文回顾了与视神经和视交叉的放射毒性与定量剂量和剂量体积测量相关的出版物。很少有研究有足够的数据用于剂量-体积结果建模。在大约 1.8 Gy/分次的剂量大于 60 Gy 和单次分割放射外科的剂量大于 12 Gy 时，毒性风险显著增加。有强有力的证据表明，分次剂量的减少会增加放射耐受性。还检查了阈耐受模型。
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