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放射性肝损伤。

Radiation-associated liver injury.

机构信息

Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-5010, USA.

出版信息

Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S94-100. doi: 10.1016/j.ijrobp.2009.06.092.

DOI:10.1016/j.ijrobp.2009.06.092
PMID:20171524
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4388033/
Abstract

The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver.

摘要

肝脏是一个极其重要的器官,具有多种功能,包括胆汁的生成、摄入营养物质的代谢、多种废物的排出、肝糖储存以及血浆蛋白的合成。在对上腹部、右下肺、远端食管的肿瘤进行放射治疗(RT)或进行全腹部或全身 RT 时,肝脏常常会意外受到照射。本文描述了肝脏接受放射的终点、时程和剂量-体积效应。

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本文引用的文献

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2
Image-guided radiotherapy for liver cancer using respiratory-correlated computed tomography and cone-beam computed tomography.使用呼吸相关计算机断层扫描和锥形束计算机断层扫描的肝癌图像引导放射治疗
Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):297-304. doi: 10.1016/j.ijrobp.2008.01.005.
3
Estimate of radiobiologic parameters from clinical data for biologically based treatment planning for liver irradiation.基于临床数据估算肝脏放疗生物治疗计划的放射生物学参数
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):900-7. doi: 10.1016/j.ijrobp.2007.10.037.
4
Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy.通用生存曲线和单次分割等效剂量:理解消融性放射治疗效能的有用工具。
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):847-52. doi: 10.1016/j.ijrobp.2007.10.059.
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Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.肝细胞癌和肝内胆管癌个体化立体定向体部放射治疗的I期研究
J Clin Oncol. 2008 Feb 1;26(4):657-64. doi: 10.1200/JCO.2007.14.3529. Epub 2008 Jan 2.
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Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):813-9. doi: 10.1016/j.ijrobp.2007.04.005. Epub 2007 May 24.
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Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis.质子束治疗严重肝硬化的肝细胞癌患者。
Strahlenther Onkol. 2006 Dec;182(12):713-20. doi: 10.1007/s00066-006-1564-2.
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