放射性肝损伤。
Radiation-associated liver injury.
机构信息
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-5010, USA.
出版信息
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S94-100. doi: 10.1016/j.ijrobp.2009.06.092.
Abstract
The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver.
摘要
肝脏是一个极其重要的器官，具有多种功能，包括胆汁的生成、摄入营养物质的代谢、多种废物的排出、肝糖储存以及血浆蛋白的合成。在对上腹部、右下肺、远端食管的肿瘤进行放射治疗（RT）或进行全腹部或全身 RT 时，肝脏常常会意外受到照射。本文描述了肝脏接受放射的终点、时程和剂量-体积效应。
相似文献
1
Radiation-associated liver injury.放射性肝损伤。
Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3 Suppl):S94-100. doi: 10.1016/j.ijrobp.2009.06.092.
2
[Doses to organs at risk in conformational and stereotactic body radiation therapy: Liver].[适形和立体定向体部放射治疗中危及器官的剂量：肝脏]
Cancer Radiother. 2017 Oct;21(6-7):604-612. doi: 10.1016/j.canrad.2017.07.042.
3
[Normal tissue tolerance to external beam radiation therapy: liver].[正常组织对外照射放射治疗的耐受性：肝脏]
Cancer Radiother. 2010 Jul;14(4-5):344-9. doi: 10.1016/j.canrad.2010.02.013. Epub 2010 Jul 2.
4
Pathology and images of radiation-induced hepatitis: a review article.放射性肝炎的病理学与影像学：一篇综述文章
Jpn J Radiol. 2018 Apr;36(4):241-256. doi: 10.1007/s11604-018-0728-1. Epub 2018 Mar 5.
5
Upper gastrointestinal tract.上消化道。
Cancer Treat Res. 2006;128:111-24. doi: 10.1007/0-387-25354-8_6.
6
Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma: in regards to Xu et al. (Int J Radiat Oncol Biol Phys 2006;65:189-195).在原发性肝癌三维适形放疗中，运用莱曼正常组织并发症概率模型预测放射性肝病：参考徐等人的研究（《国际放射肿瘤学、生物学、物理学杂志》2006年；65:189 - 195）
Int J Radiat Oncol Biol Phys. 2006 Nov 15;66(4):1272; author reply 1272-3. doi: 10.1016/j.ijrobp.2006.08.003.
7
Partial volume tolerance of the liver to radiation.肝脏对辐射的部分容积耐受性
Semin Radiat Oncol. 2005 Oct;15(4):279-83. doi: 10.1016/j.semradonc.2005.04.005.
8
Partial irradiation of the liver.肝脏的局部照射。
Semin Radiat Oncol. 2001 Jul;11(3):240-6. doi: 10.1053/srao.2001.23485.
9
Dosimetric analysis of liver toxicity after liver metastasis stereotactic body radiation therapy.肝脏转移立体定向体部放射治疗后肝脏毒性的剂量学分析。
Pract Radiat Oncol. 2017 Sep-Oct;7(5):e331-e337. doi: 10.1016/j.prro.2017.03.004. Epub 2017 Mar 9.
10
Probability of radiation-induced complications in normal tissues with parallel architecture under conditions of uniform whole or partial organ irradiation.在整个器官或部分器官均匀照射条件下，平行结构正常组织中辐射诱发并发症的概率。
Radiother Oncol. 1993 Mar;26(3):226-37. doi: 10.1016/0167-8140(93)90264-9.
引用本文的文献
1
Comprehensive analysis of the role of deep inspiration breath-hold in right-sided breast cancer radiotherapy: A focus on cardiac substructures and right coronary artery.深吸气屏气在右侧乳腺癌放疗中作用的综合分析：聚焦心脏亚结构和右冠状动脉
J Appl Clin Med Phys. 2025 Sep;26(9):e70216. doi: 10.1002/acm2.70216.
2
Simultaneous integrated boost and protection proton beam therapy approach for hepatocellular carcinoma.肝细胞癌的同步集成增强与保护质子束治疗方法
Clin Transl Radiat Oncol. 2025 Jul 1;54:101008. doi: 10.1016/j.ctro.2025.101008. eCollection 2025 Sep.
3
MRI for biology-guided radiation therapy: Are we there yet? A summary of the 2024 ISMRM member-initiated session.用于生物引导放射治疗的磁共振成像：我们做到了吗？2024年国际磁共振医学学会会员发起会议总结
Magn Reson Med. 2025 Oct;94(4):1672-1683. doi: 10.1002/mrm.30616. Epub 2025 Jun 24.
4
Risk Factors of Non-Classic Radiation-Induced Liver Disease (ncRILD) After Intensity-Modulated Radiotherapy in Hepatocellular Carcinoma.肝细胞癌调强放疗后非典型放射性肝病（ncRILD）的危险因素
Cancer Manag Res. 2025 Jun 18;17:1169-1183. doi: 10.2147/CMAR.S539527. eCollection 2025.
5
Radiomics of Dynamic Contrast-Enhanced MRI for Predicting Radiation-Induced Hepatic Toxicity After Intensity Modulated Radiotherapy for Hepatocellular Carcinoma: A Machine Learning Predictive Model Based on the SHAP Methodology.动态对比增强磁共振成像的影像组学用于预测肝细胞癌调强放疗后放射性肝毒性：基于SHAP方法的机器学习预测模型
J Hepatocell Carcinoma. 2025 May 17;12:999-1015. doi: 10.2147/JHC.S523448. eCollection 2025.
6
Radiation induced liver injury (RILI) evaluation using longitudinal computed tomography (CT) in image-guided precision murine radiotherapy.在图像引导的精确小鼠放射治疗中，使用纵向计算机断层扫描（CT）评估辐射诱导的肝损伤（RILI）。
Precis Radiat Oncol. 2024 Nov 9;8(4):182-190. doi: 10.1002/pro6.1244. eCollection 2024 Dec.
7
Efficacy and safety of radiotherapy to delay second-line systemic therapy in patients with oligoprogressive hepatocellular carcinoma: study protocol of a multicentre, single-arm, phase II trial.放疗延缓寡进展期肝细胞癌患者二线全身治疗的疗效和安全性：一项多中心、单臂、II期试验的研究方案
Ther Adv Med Oncol. 2025 Apr 23;17:17588359251334538. doi: 10.1177/17588359251334538. eCollection 2025.
8
Liver quad culture chip as a model for radiation injury research.肝四元培养芯片作为辐射损伤研究的模型
Sci Rep. 2025 Apr 11;15(1):12414. doi: 10.1038/s41598-025-96140-1.
9
Assessing the Relationship Between MR-Based Functional Dose Metrics and Post-Stereotactic Body Radiation Therapy Albumin-Bilirubin Change.评估基于磁共振成像的功能剂量指标与立体定向体部放射治疗后白蛋白-胆红素变化之间的关系。
Int J Radiat Oncol Biol Phys. 2025 Jul 1;122(3):690-697. doi: 10.1016/j.ijrobp.2025.03.054. Epub 2025 Mar 31.
10
Dose-Volume Constraints for Thoracic, Abdominal, and Pelvic Carbon Ion Radiotherapy: A Literature Review.胸、腹及盆腔碳离子放射治疗的剂量-体积限制：文献综述
Cancer Med. 2025 Apr;14(7):e70840. doi: 10.1002/cam4.70840.
本文引用的文献
1
Phase I study of individualized stereotactic body radiotherapy of liver metastases.肝转移瘤个体化立体定向体部放射治疗的I期研究
J Clin Oncol. 2009 Apr 1;27(10):1585-91. doi: 10.1200/JCO.2008.20.0600. Epub 2009 Mar 2.
2
Image-guided radiotherapy for liver cancer using respiratory-correlated computed tomography and cone-beam computed tomography.使用呼吸相关计算机断层扫描和锥形束计算机断层扫描的肝癌图像引导放射治疗
Int J Radiat Oncol Biol Phys. 2008 May 1;71(1):297-304. doi: 10.1016/j.ijrobp.2008.01.005.
3
Estimate of radiobiologic parameters from clinical data for biologically based treatment planning for liver irradiation.基于临床数据估算肝脏放疗生物治疗计划的放射生物学参数
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):900-7. doi: 10.1016/j.ijrobp.2007.10.037.
4
Universal survival curve and single fraction equivalent dose: useful tools in understanding potency of ablative radiotherapy.通用生存曲线和单次分割等效剂量：理解消融性放射治疗效能的有用工具。
Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):847-52. doi: 10.1016/j.ijrobp.2007.10.059.
5
Phase I study of individualized stereotactic body radiotherapy for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.肝细胞癌和肝内胆管癌个体化立体定向体部放射治疗的I期研究
J Clin Oncol. 2008 Feb 1;26(4):657-64. doi: 10.1200/JCO.2007.14.3529. Epub 2008 Jan 2.
6
Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma.乙型肝炎病毒相关肝细胞癌患者三维适形放疗后乙肝病毒再激活
Int J Radiat Oncol Biol Phys. 2007 Nov 1;69(3):813-9. doi: 10.1016/j.ijrobp.2007.04.005. Epub 2007 May 24.
7
Proton beam therapy for hepatocellular carcinoma patients with severe cirrhosis.质子束治疗严重肝硬化的肝细胞癌患者。
Strahlenther Onkol. 2006 Dec;182(12):713-20. doi: 10.1007/s00066-006-1564-2.
8
Dose-volumetric parameters predicting radiation-induced hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal radiotherapy.预测接受三维适形放疗的不可切除肝细胞癌患者放射性肝毒性的剂量-体积参数。
Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):225-31. doi: 10.1016/j.ijrobp.2006.08.015. Epub 2006 Oct 23.
9
Interim analysis of a prospective phase I/II trial of SBRT for liver metastases.立体定向体部放疗（SBRT）治疗肝转移瘤的前瞻性I/II期试验的中期分析。
Acta Oncol. 2006;45(7):848-55. doi: 10.1080/02841860600904870.
10
Stereotactic body radiation therapy for primary and metastatic liver tumors: A single institution phase i-ii study.立体定向体部放射治疗原发性和转移性肝肿瘤：一项单机构的I-II期研究。
Acta Oncol. 2006;45(7):831-7. doi: 10.1080/02841860600897934.
Zotero 插件