Yorke E D, Kutcher G J, Jackson A, Ling C C
George Washington University Hospital, Washington, DC 20037.
Radiother Oncol. 1993 Mar;26(3):226-37. doi: 10.1016/0167-8140(93)90264-9.
A biologically based model is developed for normal tissue complication probability as a function of dose and irradiated volume fraction for organs such as the kidney and the lung. The organ is assumed to be composed of functional subunits (FSUs) which are arranged in a parallel architecture. The complication is produced only if a sufficiently large fraction of the FSUs are inactivated by radiation and an FSU is inactivated only when all the clonogenic cells within it are killed. The linear-quadratic model is used for the dose-response of individual cells within an FSU. The predictions of this model are compared with those of an empirical power law function for uniform whole and partial organ irradiation.
针对肾脏和肺等器官，建立了一个基于生物学的正常组织并发症概率模型，该模型是剂量和受照体积分数的函数。假定器官由以平行结构排列的功能亚单位（FSU）组成。只有当足够大比例的FSU被辐射失活时才会产生并发症，并且只有当FSU内所有克隆源性细胞都被杀死时，该FSU才会失活。线性二次模型用于FSU内单个细胞的剂量反应。将该模型的预测结果与均匀全器官和部分器官照射的经验幂律函数的预测结果进行比较。
