Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
J Chin Med Assoc. 2010 Feb;73(2):101-3. doi: 10.1016/S1726-4901(10)70010-1.
Metastases of prostate cancer to the penis and urethra are rare and often represent advanced disease. We describe a case of newly diagnosed prostatic adenocarcinoma with metastases to the corpus spongiosum, cavernosum, and the anterior urethra. A male patient, 77 years of age, initially had lower urinary tract obstruction symptoms. His prostate-specific antigen level was 5.02 ng/mL. Digital rectal examination disclosed stony hard tumors at both lobes of the prostate. Transrectal ultrasound-guided biopsy of the prostate revealed adenocarcinoma over both lobes; the Gleason score was 4 + 4 = 8. Cystoscopy showed a penile urethral tumor and biopsy disclosed metastatic adenocarcinoma of the prostate; the Gleason score was 4 + 4 = 8. The patient initially received hormone therapy. Biochemical failure developed after 15 months and rapidly progressed to a hormone-refractory stage. Docetaxel was then prescribed. The patient died in the 25(th) month after the diagnosis.
前列腺癌转移至阴茎和尿道较为罕见，往往代表疾病已进展至晚期。我们描述了一例新诊断的前列腺腺癌，其转移至海绵体和尿道球部、尿道海绵体。一名 77 岁男性，最初出现下尿路梗阻症状。其前列腺特异性抗原水平为 5.02ng/mL。直肠指检发现前列腺两叶均有坚硬的肿瘤。经直肠超声引导下前列腺活检显示两叶均为腺癌；Gleason 评分为 4+4=8。膀胱镜检查显示阴茎尿道肿瘤，活检显示前列腺转移性腺癌；Gleason 评分为 4+4=8。患者最初接受激素治疗。15 个月后发生生化失败，并迅速进展至激素难治阶段。随后给予多西他赛治疗。诊断后第 25 个月患者死亡。
