Laboratory for Biomechanics and Biomaterials, Department of Orthopaedic Surgery, Hannover Medical School, Anna-von-Borries-Str 1-7, 30625 Hannover, Germany.
Acta Biomater. 2010 May;6(5):1680-92. doi: 10.1016/j.actbio.2010.02.028. Epub 2010 Feb 19.
Today, more than 200years after the first production of metallic magnesium by Sir Humphry Davy in 1808, biodegradable magnesium-based metal implants are currently breaking the paradigm in biomaterial science to develop only highly corrosion resistant metals. This groundbreaking approach to temporary metallic implants is one of the latest developments in biomaterials science that is being rediscovered. It is a challenging topic, and several secrets still remain that might revolutionize various biomedical implants currently in clinical use. Magnesium alloys were investigated as implant materials long ago. A very early clinical report was given in 1878 by the physician Edward C. Huse. He used magnesium wires as ligature for bleeding vessels. Magnesium alloys for clinical use were explored during the last two centuries mainly by surgeons with various clinical backgrounds, such as cardiovascular, musculoskeletal and general surgery. Nearly all patients benefited from the treatment with magnesium implants. Although most patients experienced subcutaneous gas cavities caused by rapid implant corrosion, most patients had no pain and almost no infections were observed during the postoperative follow-up. This review critically summarizes the in vitro and in vivo knowledge and experience that has been reported on the use of magnesium and its alloys to advance the field of biodegradable metals.
如今，距离 Humphry Davy 爵士于 1808 年首次生产金属镁已经过去了 200 多年，可生物降解的镁基金属植入物目前正在打破生物材料科学的范式，不再仅仅开发高耐腐蚀金属。这种开发临时金属植入物的开创性方法是生物材料科学中最新的发展之一，正在被重新发现。这是一个具有挑战性的话题，仍有一些秘密有待揭示，这些秘密可能会彻底改变目前临床使用的各种生物医学植入物。很久以前，人们就研究过镁合金作为植入物材料。早在 1878 年，医生 Edward C. Huse 就发表了一篇非常早期的临床报告。他使用镁线作为结扎血管的结扎线。在过去的两个世纪里，主要是具有心血管、肌肉骨骼和普通外科等各种临床背景的外科医生探索了用于临床的镁合金。几乎所有接受镁植入物治疗的患者都从中受益。尽管大多数患者经历了因植入物快速腐蚀而导致的皮下气腔，但大多数患者在术后随访期间没有疼痛，几乎没有观察到感染。这篇综述批判性地总结了已报道的关于使用镁及其合金来推进可生物降解金属领域的体外和体内知识和经验。
