Martinez Sanchez Adela Helvia, Luthringer Bérengère J C, Feyerabend Frank, Willumeit Regine
Institute of Materials Research, Department for Structural Research on Macromolecules, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany.
Institute of Materials Research, Department for Structural Research on Macromolecules, Helmholtz-Zentrum Geesthacht (HZG), Geesthacht, Germany.
Acta Biomater. 2015 Feb;13:16-31. doi: 10.1016/j.actbio.2014.11.048. Epub 2014 Dec 4.
Due to their biodegradability, magnesium and magnesium-based alloys could represent the third generation of biomaterials. However, their mechanical properties and time of degradation have to match the needs of applications. Several approaches, such as choice of alloying elements or tailored microstructure, are employed to tailor corrosion behaviour. Due to the high electrochemical activity of Mg, numerous environmental factors (e.g. temperature and surrounding ion composition) influence its corrosion behaviour, making it unpredictable. Nevertheless, the need of reliable in vitro model(s) to predict in vivo implant degradation is increasing. In an attempt to find a correlation between in vitro and vivo corrosion rates, this review presents a systematic literature survey, as well as an attempt to correlate the different results.
由于镁及镁基合金具有生物可降解性，它们有望成为第三代生物材料。然而，其机械性能和降解时间必须满足应用需求。人们采用了多种方法，如选择合金元素或定制微观结构，来调整腐蚀行为。由于镁的电化学活性高，许多环境因素（如温度和周围离子组成）都会影响其腐蚀行为，使其难以预测。尽管如此，预测体内植入物降解的可靠体外模型的需求日益增加。为了找到体外和体内腐蚀速率之间的相关性，本综述进行了系统的文献调查，并试图关联不同的结果。
