Drago H, Marín G H, Sturla F, Roque G, Mártire K, Díaz Aquino V, Lamonega R, Gardiner C, Ichim T, Riordan N, Raimondi J C, Bossi S, Samadikuchaksaraei A, van Leeuwen M, Tau J M, Núñez L, Larsen G, Spretz R, Mansilla E
Banco de Tejidos, Hospital de Quemados, CABA, Argentina.
Transplant Proc. 2010 Jan-Feb;42(1):345-9. doi: 10.1016/j.transproceed.2009.11.031.
We describe a novel technology based on nanoengineered multifunctional acellular biologic scaffolds combined with wound dressings and films of the same kind. This method allows selective delivery and release of shielded biomaterials and bioactive substances to a desired wound or damaged tissue while stimulating the selective anchoring and adhesion of endogenous circulating repairing cells, such as mesenchymal stem cells, to obtain a faster and more physiologic healing process. We also present a new controlled enzymatic debridement process for more effective burned tissue scarolysis. In light of our preliminary in vitro and in vivo data, we are convinced that these approaches can include the use of other kinds of adult stem cells, such as endometrial regenerative cells, to improve the vascularization of the constructs, with great potential in the entire tissue and organ regeneration field but especially for the treatment of severely burned patients, changing the way these lesions may be treated in the future.
我们描述了一种基于纳米工程多功能无细胞生物支架的新技术，该支架与同类伤口敷料和薄膜相结合。这种方法允许将屏蔽的生物材料和生物活性物质选择性地输送和释放到所需的伤口或受损组织，同时刺激内源性循环修复细胞（如间充质干细胞）的选择性锚定和粘附，以获得更快、更生理的愈合过程。我们还提出了一种新的可控酶清创过程，用于更有效地溶解烧伤组织瘢痕。根据我们初步的体外和体内数据，我们相信这些方法可以包括使用其他种类的成体干细胞，如子宫内膜再生细胞，以改善构建体的血管化，在整个组织和器官再生领域具有巨大潜力，尤其是对于严重烧伤患者的治疗，可能会改变未来治疗这些损伤的方式。
