评估小儿单侧听力损失研究中的自我选择偏倚。
Assessment of self-selection bias in a pediatric unilateral hearing loss study.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Washington University, St. Louis, MO 63110, USA.
出版信息
Otolaryngol Head Neck Surg. 2010 Mar;142(3):427-33. doi: 10.1016/j.otohns.2009.11.035.
OBJECTIVE
To examine the differences between participants and nonparticipants in a study of children with unilateral hearing loss that might contribute to selection bias.
STUDY DESIGN
Case-control study.
SETTING
Academic pediatric otolaryngology practice.
SUBJECTS AND METHODS
Comparison of clinical and sociodemographic characteristics between the 81 participants and 78 nonparticipants with unilateral hearing loss in a case-control study.
RESULTS
Compared with nonparticipants, the study participants were younger but were diagnosed at an older age. Participants were more likely to have been diagnosed through a primary care screen and have normal ear anatomy, and less likely to have an attributed etiology for their unilateral hearing loss or tried assistive hearing devices. No other significant demographic, socioeconomic, or clinical differences were identified.
CONCLUSION
Self-selection bias may jeopardize both internal and external validity of study results and should be evaluated whenever possible. Methods to minimize self-selection bias should be considered and implemented during the planning stages of clinical studies.
目的
研究单侧听力损失患儿研究中的参与者与非参与者之间的差异，这些差异可能导致选择偏倚。
研究设计
病例对照研究。
设置
学术儿科耳鼻喉科实践。
受试者和方法
对单侧听力损失的 81 名参与者和 78 名非参与者的临床和社会人口统计学特征进行比较，这些参与者均来自病例对照研究。
结果
与非参与者相比，研究参与者年龄较小，但诊断年龄较大。参与者更有可能通过初级保健筛查进行诊断，且具有正常的耳部解剖结构，而不太可能单侧听力损失归因于特定病因，或尝试过助听设备。没有发现其他明显的人口统计学、社会经济或临床差异。
结论
自我选择偏倚可能危及研究结果的内部和外部有效性，应尽可能进行评估。在临床研究的规划阶段，应考虑并实施最小化自我选择偏倚的方法。
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