Key Laboratory of Clinical Medicine, Zhengzhou, Henan Province, China.
J Urol. 2010 Apr;183(4):1533-7. doi: 10.1016/j.juro.2009.12.040. Epub 2010 Feb 20.
We investigated the clinical diagnosis and treatment features of bilateral renal calculi in young children who ingested melamine tainted infant milk formula.
We retrospectively analyzed clinical data on 50 children (mean +/- SE age 23.4 +/- 3.1 months) with a history of ingesting melamine tainted infant milk formula and suffering from bilateral renal calculi. All patients underwent ultrasound and renal function evaluation. Treatment included cessation of melamine tainted formula consumption, hydration, urine basification and hemodialysis if necessary.
Bilateral renal calculi peaked in 6 to 18-month-olds (58% of cases). The male-to-female ratio was 3.1:1.0. Calculi ranged in diameter from 4 to 10 mm in 33 patients (66%) and 2.5 to 4 mm in 17 (34%). Of the 11 patients with renal failure 8 underwent 1 to 4 sessions of hemodialysis. Of the 9 bilateral obstruction cases with renal failure 8 did not require surgical intervention but 1 required ureteral catheterization to drain the renal pelvis. All children experienced a good outcome and were discharged home after a mean +/- SE hospitalization of 8.1 +/- 0.7 days.
Melamine related urinary calculi were most often seen in patients 6 to 18 months old. Conservative management has been sufficient in most cases. However, these children need to be monitored for long-term effects of melamine tainted milk formula consumption.
我们调查了摄入三聚氰胺污染婴儿配方奶粉的婴幼儿双侧肾结石的临床诊断和治疗特点。
我们回顾性分析了 50 例（平均年龄 23.4 ± 3.1 个月）有三聚氰胺污染婴儿配方奶粉摄入史并患有双侧肾结石的儿童的临床资料。所有患者均行超声和肾功能评估。治疗包括停止摄入三聚氰胺污染配方奶、水化、尿液碱化和必要时行血液透析。
双侧肾结石在 6-18 个月龄儿童中最为常见（占 58%）。男女比例为 3.1:1.0。结石直径 33 例（66%）为 4-10mm，17 例（34%）为 2.5-4mm。11 例肾功能衰竭患者中有 8 例接受了 1-4 次血液透析。9 例双侧梗阻合并肾功能衰竭患者中，8 例无需手术干预，但 1 例需要输尿管置管引流肾盂。所有儿童均预后良好，平均住院 8.1 ± 0.7 天后出院。
三聚氰胺相关尿路结石多见于 6-18 个月龄儿童。大多数情况下保守治疗即可。然而，这些儿童需要长期监测三聚氰胺污染配方奶粉摄入的长期影响。
