Faculty of Agriculture, Iwate University, Morioka, Japan.
Domest Anim Endocrinol. 2010 Jul;39(1):21-5. doi: 10.1016/j.domaniend.2010.01.002. Epub 2010 Feb 2.
The aims of the present study were to clarify the effect of salsolinol (SAL), a dopamine (DA)-derived endogenous compound, on the secretion of prolactin (PRL) in cattle. The experiments were performed from April to June using calves and cows. A single intravenous (i.v.) injection of SAL (5mg/kg body weight [BW]) or sulpiride (a DA receptor antagonist, 0.1mg/kg BW) significantly stimulated the release of PRL in male and female calves (P<0.05), though the response to SAL was smaller than that to sulpiride. The secretory pattern of PRL in response to SAL or sulpiride in female calves resembled that in male calves. A single i.v. injection of SAL or sulpiride significantly stimulated the release of PRL in cows (P<0.05). There was no significant difference in the PRL-releasing response between the SAL- and sulpiride-injected groups in cows. A single intracerebroventricular injection of SAL (10mg/head) also significantly stimulated the release of PRL in castrated calves (P<0.05). These results show that SAL is involved in the regulatory process for the secretion of PRL, not only in male and female calves, but also in cows. The results also suggest that the potency of the PRL-releasing response to SAL differs with the physiological status of cattle.
本研究旨在阐明内源性多巴胺衍生化合物——红古豆醇（SAL）对牛催乳素（PRL）分泌的影响。实验于 4 月至 6 月期间在小牛和奶牛中进行。单次静脉（i.v.）注射 SAL（5mg/kg 体重[BW]）或舒必利（一种多巴胺受体拮抗剂，0.1mg/kg BW）可显著刺激雄性和雌性小牛 PRL 的释放（P<0.05），尽管 SAL 的反应小于舒必利。SAL 或舒必利对雌性小牛 PRL 的分泌模式与雄性小牛相似。单次 i.v.注射 SAL 或舒必利可显著刺激奶牛 PRL 的释放（P<0.05）。在奶牛中，SAL 和舒必利注射组之间的 PRL 释放反应没有显著差异。单次侧脑室注射 SAL（10mg/头）也可显著刺激去势小牛 PRL 的释放（P<0.05）。这些结果表明，SAL 参与了 PRL 分泌的调节过程，不仅在雄性和雌性小牛中，而且在奶牛中也是如此。结果还表明，SAL 对 PRL 释放反应的效力因牛的生理状态而异。
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