水溶性[60]富勒烯衍生物的合成及其对 NGF 处理的 PC12 细胞突起生长的增强作用。

Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells.

机构信息

Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi, Japan.

出版信息

Bioorg Med Chem Lett. 2010 Mar 15;20(6):1948-52. doi: 10.1016/j.bmcl.2010.01.142. Epub 2010 Feb 2.

DOI:10.1016/j.bmcl.2010.01.142

PMID:20172723

Abstract

Water-soluble [60]fullerene (C(60)) derivatives were synthesized to examine their bioactivities. PC12 cells were used as a model of nerve cells and the bioactivities of synthesized C(60) derivatives together with some reported ones were tested. Among the compounds tested, C(60)/(gamma-CyD)(2), C(60)-bis(gamma-CyD) (5) containing C(60)-mono(gamma-CyD) (5'), and C(60)/PVP were sufficiently soluble in water and showed an enhancing effect on the neurite outgrowth of NGF-treated PC12 cells.

摘要

水溶性[60]富勒烯（C（60））衍生物被合成以研究它们的生物活性。PC12 细胞被用作神经细胞模型，测试了合成的 C（60）衍生物以及一些已报道的衍生物的生物活性。在所测试的化合物中，C（60）/（γ-CyD）（2）、C（60）-双（γ-CyD）（5）含有 C（60）-单（γ-CyD）（5'）和 C（60）/PVP 在水中有足够的溶解性，并对 NGF 处理的 PC12 细胞的突起生长有增强作用。