Chu Minglei, Gao Huichang, Liu Sa, Wang Lin, Jia Yongguang, Gao Meng, Wan Miaojian, Xu Chengfang, Ren Li
School of Materials Science and Engineering, South China University of Technology Guangzhou 510641 China
Center for Medical Device Evaluation, China Food and Drug Administration Beijing 100081 China.
RSC Adv. 2018 May 17;8(33):18197-18203. doi: 10.1039/c8ra03965h.
A series of novel bacterial cellulose/C (BCC) composites was prepared using a original dehydration-rehydration method. The composites were characterized to demonstrate their potential in multifunctional wound dressings for skin cancer treatment using photodynamic therapy. Raman spectroscopy revealed that the C nanoparticles were successfully incorporated into the bacterial cellulose (BC) network. Scanning electron microscopy was used to examine the morphology and distribution of the C particles as photosensitizers in the bacterial cellulose network, and the C particles were uniformly distributed in the hyperfine three-dimensional BC network with diameters less than 100 nm. Reactive oxygen species (ROS) measurements indicated that the BCC composites possessed a high ROS generation ability when exposed to light. The antibacterial assessment of the BCC composites revealed their ability to inhibit the growth of and and their relationship with light irradiation. cell experiments also confirmed that the BCC composites had low cytotoxicity in the dark, while they exhibited significant cancer cell damage activity under visible light.
采用一种原始的脱水-再水化方法制备了一系列新型细菌纤维素/C（BCC）复合材料。对这些复合材料进行了表征，以证明它们在使用光动力疗法治疗皮肤癌的多功能伤口敷料中的潜力。拉曼光谱表明，C纳米颗粒已成功掺入细菌纤维素（BC）网络中。使用扫描电子显微镜检查了作为光敏剂的C颗粒在细菌纤维素网络中的形态和分布，C颗粒均匀分布在直径小于100nm的超精细三维BC网络中。活性氧（ROS）测量表明，BCC复合材料在光照下具有高ROS生成能力。BCC复合材料的抗菌评估揭示了它们抑制和生长的能力以及它们与光照射的关系。细胞实验还证实，BCC复合材料在黑暗中具有低细胞毒性，而在可见光下它们表现出显著的癌细胞损伤活性。
