Norwegian PSC Research Center, Medical Department, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Dig Liver Dis. 2010 Jun;42(6):390-400. doi: 10.1016/j.dld.2010.01.011. Epub 2010 Feb 20.
Early studies in primary sclerosing cholangitis (PSC) were concerned with disease characterization, and were followed by epidemiological studies of PSC and clinical subsets of PSC as well as a large number of treatment trials. Recently, the molecular pathogenesis and the practical handling of the patients have received increasing attention. In the present review we aim to give an update on the pathogenesis of PSC and cholangiocarcinoma in PSC, as well as to discuss the current opinion on diagnosis and treatment of PSC in light of the recent European Association for the Study of the Liver and the American Association for the Study of Liver Diseases practice guidelines.
原发性硬化性胆管炎（PSC）的早期研究主要集中在疾病特征上，随后是 PSC 和 PSC 的临床亚型的流行病学研究以及大量的治疗试验。最近，分子发病机制和患者的实际处理受到了越来越多的关注。在本次综述中，我们旨在介绍 PSC 的发病机制和 PSC 中的胆管癌，并根据最近的欧洲肝脏研究协会和美国肝脏研究协会实践指南，讨论当前对 PSC 的诊断和治疗的看法。
