Fung Brian M, Tabibian James H
University of California Los Angeles-Olive View Internal Medicine Residency Program, Sylmar, CA, USA.
Division of Gastroenterology, Department of Medicine, Olive View-University of California Los Angeles Medical Center, Sylmar, CA, USA.
Liver Res. 2019 Jun;3(2):106-117. doi: 10.1016/j.livres.2019.03.004. Epub 2019 Apr 3.
Primary sclerosing cholangitis (PSC) is a chronic, idiopathic, cholestatic liver disease characterized by inflammation and fibrosis of the intrahepatic and/or extrahepatic bile ducts. It can affect individuals of all age groups and gender, has no established pharmacotherapy, and is associated with a variety of neoplastic ( cholangiocarcinoma) and non-neoplastic ( dominant strictures) hepatobiliary complications. Given these considerations, endoscopy plays a major role in the care of patients with PSC. In this review, we discuss and provide updates regarding endoscopic considerations in the management of hepatobiliary manifestations and complications of PSC. Where evidence is limited, we suggest pragmatic approaches based on currently available data and expert opinion.
原发性硬化性胆管炎（PSC）是一种慢性、特发性胆汁淤积性肝病，其特征为肝内和/或肝外胆管的炎症和纤维化。它可影响所有年龄组和性别的个体，尚无既定的药物治疗方法，且与多种肿瘤性（胆管癌）和非肿瘤性（主导管狭窄）肝胆并发症相关。鉴于这些因素，内镜检查在PSC患者的治疗中起着主要作用。在本综述中，我们讨论并提供有关PSC肝胆表现和并发症管理中内镜检查注意事项的最新信息。在证据有限的情况下，我们根据现有数据和专家意见提出实用的方法。
