Department of Radiology, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
J Clin Endocrinol Metab. 2010 Apr;95(4):1932-8. doi: 10.1210/jc.2009-2076. Epub 2010 Feb 19.
Skeletal muscle and cardiac lipid accumulation are associated with diminished insulin sensitivity and cardiac function, respectively. In skeletal muscle, physical activity paradoxically increases fat accumulation, despite improvement in insulin sensitivity. Whether cardiac muscle responds similarly remains unknown.
The objective of the study was to investigate cardiac lipid content and cardiac function after a 12-wk training program.
This was an intervention study with pre/postmeasurements.
The study was conducted at Maastricht University Medical Center.
Participants included 14 healthy, male overweight/obese subjects (age 58.4 +/- 0.9 yr, body mass index 29.9 +/- 0.01 kg/m(2)).
Intervention included a supervised 12-wk training program with three sessions per week (endurance and strength training).
Maximal whole-body oxygen uptake, fasting plasma parameters, systolic function (by CINE-magnetic resonance imaging), and cardiac lipid content (by proton magnetic resonance spectroscopy) were measured.
Maximal whole-body oxygen uptake increased (from 2559 +/- 131 to 2702 +/- 124 ml/min after training, P = 0.05). Plasma concentrations of glucose decreased (from 6.3 +/- 0.2 to 5.7 +/- 0.2 mmol/liter, P < 0.001); plasma triacylglycerols and (free) fatty acids did not change. Also, body weight (from 94.2 +/- 3.6 to 92.9 +/- 3.6 kg, P = 0.10) and fat percentage (from 33.6 +/- 1.7 to 32.5 +/- 2.0%, P = 0.14) was unchanged. Left ventricular ejection fraction improved (from 52.2 +/- 1.3 to 54.2 +/- 1.2%, P = 0.02), and cardiac lipid content in the septum was decreased after training (0.99 +/- 0.15 to 0.54 +/- 0.04%, P = 0.02).
Twelve weeks of endurance/strength training significantly reduced cardiac lipid content in overweight subjects and was paralleled by improved ejection fraction. This is in line with a lipotoxic action of (excess) cardiac lipids on cardiac function, although a causal relationship cannot be derived from this study. Further research is needed to clarify the clinical relevance of cardiac lipid content in the etiology of cardiovascular complications.
骨骼肌和心肌的脂质堆积分别与胰岛素敏感性降低和心脏功能障碍有关。在骨骼肌中，尽管胰岛素敏感性提高，但体育活动却反常地增加脂肪堆积。心肌是否也有类似的反应尚不清楚。
本研究旨在调查 12 周训练计划后心脏的脂质含量和心脏功能。
这是一项具有前后测量的干预研究。
研究在马斯特里赫特大学医学中心进行。
参与者包括 14 名健康的超重/肥胖男性（年龄 58.4 +/- 0.9 岁，体重指数 29.9 +/- 0.01 kg/m(2)）。
干预包括每周三次的监督 12 周训练计划（耐力和力量训练）。
最大全身耗氧量、空腹血浆参数、收缩功能（通过 CINE-磁共振成像）和心脏脂质含量（通过质子磁共振波谱）。
最大全身耗氧量增加（从训练前的 2559 +/- 131 增加到训练后的 2702 +/- 124 ml/min，P = 0.05）。血浆葡萄糖浓度降低（从 6.3 +/- 0.2 降低到 5.7 +/- 0.2 mmol/liter，P < 0.001）；血浆三酰甘油和（游离）脂肪酸没有变化。此外，体重（从 94.2 +/- 3.6 减少到 92.9 +/- 3.6 kg，P = 0.10）和脂肪百分比（从 33.6 +/- 1.7 减少到 32.5 +/- 2.0%，P = 0.14）保持不变。左心室射血分数改善（从 52.2 +/- 1.3 增加到 54.2 +/- 1.2%，P = 0.02），并且训练后室间隔的心脏脂质含量降低（从 0.99 +/- 0.15 降低到 0.54 +/- 0.04%，P = 0.02）。
12 周的耐力/力量训练显著降低了超重受试者的心脏脂质含量，并伴有射血分数的改善。这与（过多）心脏脂质对心脏功能的脂毒性作用一致，尽管不能从这项研究中得出因果关系。需要进一步研究以阐明心脏脂质含量在心血管并发症发病机制中的临床相关性。
