Groblewska Magdalena, Mroczko Barbara, Szmitkowski Maciej
Zakład Diagnostyki Biochemicznej Uniwersytetu Medycznego w Białymstoku, ul. Waszyngtona 15a, 15-269 Białystok.
Postepy Hig Med Dosw (Online). 2010 Jan 26;64:22-30.
Colorectal cancer is one of the most common malignant tumors of the gastrointestinal tract. The development of this tumor is a complex, long-term, and multi-step process, from small dysplastic lesions of normal colorectal mucosa, through adenomatous polyps, to carcinoma in situ. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play an important role in colorectal carcinogenesis. MMP-9 is able to degrade collagen IV from basement membranes and extracellular matrix, which is associated with tumor progression, including invasion, metastasis,growth, migration, and angiogenesis. It was demonstrated that increased expression of MMP-9plays a crucial role in the development of several human malignancies, including colorectal cancer.Increased expression of MMP-9 correlated with tumor stage, invasiveness, and poor survival of colorectal cancer patients.
结直肠癌是胃肠道最常见的恶性肿瘤之一。该肿瘤的发生发展是一个复杂、长期且多步骤的过程，从正常结直肠黏膜的小发育异常病变，经过腺瘤性息肉，发展到原位癌。基质金属蛋白酶（MMPs）及其组织抑制剂（TIMPs）在结直肠癌发生过程中起重要作用。MMP-9能够降解基底膜和细胞外基质中的IV型胶原蛋白，这与肿瘤进展相关，包括侵袭、转移、生长、迁移和血管生成。研究表明，MMP-9表达增加在包括结直肠癌在内的多种人类恶性肿瘤的发生发展中起关键作用。MMP-9表达增加与结直肠癌患者的肿瘤分期、侵袭性及不良生存相关。
