First Department of Propaedeutic Medicine, Laiko University General Hospital, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.
Eur J Gastroenterol Hepatol. 2010 May;22(5):614-9. doi: 10.1097/MEG.0b013e328335ef50.
This study aimed at investigating whether a differential estrogen receptor beta (ER-beta) expression between the colonic subsites could correspond to a modification in proliferation, apoptosis, and adhesion of the normal colonocytes.
ER-beta, Ki-67, Bcl-2, and E-cadherin expressions were investigated immunohistochemically, in normal epithelium biopsies from the ascending and the descending colon of 53 individuals, who underwent colonoscopy for the investigation of anemia and in whom no local pathology was identified.
ER-beta immunoreactivity has been shown to be stronger at the superficial epithelium than the crypts' base, the difference being important only for the ascending colon. In addition, ER-beta expression was higher in the superficial epithelium of the ascending colon than that of the descending colon. The variations of ER-beta expression did not correspond to the alterations in Ki-67, Bcl-2, and E-cadherin expression.
A subsite-specific variation of ER-beta expression has been shown in the normal colonic epithelium. This modulation of ER-beta might account for some well established specificities of colorectal cancer epidemiology like the right-sided predominance of the neoplasm in women and its gradual shift to more proximal sites over time.
本研究旨在探讨结肠不同部位雌激素受体β（ER-β）表达的差异是否与正常结肠细胞增殖、凋亡和黏附的改变有关。
对 53 例行结肠镜检查以贫血为主要症状且无局部病变的个体的升结肠和降结肠的正常上皮活检组织进行了 ER-β、Ki-67、Bcl-2 和 E-cadherin 的免疫组织化学检测。
与隐窝基底相比，ER-β 在结肠表面上皮的免疫反应性更强，这种差异仅在升结肠中较为显著。此外，升结肠表面上皮的 ER-β 表达高于降结肠。ER-β 表达的变化与 Ki-67、Bcl-2 和 E-cadherin 表达的变化无关。
在正常结肠上皮中观察到 ER-β 表达的部位特异性变化。这种 ER-β 的调节可能解释了一些已确立的结直肠癌流行病学的特异性，如女性肿瘤右侧优势以及随着时间的推移肿瘤逐渐向近端转移的趋势。
