Department of Pathology, Hôpital St-Antoine, AP-HP, Paris, France.
Pancreas. 2010 Jul;39(5):577-80. doi: 10.1097/MPA.0b013e3181c75f74.
Metastatic tumors to the pancreas are rare and usually present a part of an advanced metastatic disease. Isolated metastasis is even rarer and may be difficult to differentiate from primary pancreatic neoplasm. The leading sources of metastases are breast, lung, kidney, and skin (melanoma). We present our experience with 12 cases of isolated pancreatic metastasis.
We made a retrospective review from a series of pancreatic resections for metastatic disease, which occurred during the last decade.
The sites of origin were as follows: kidney (8 cases), lung (2 cases), bone (1 case), and breast (1 case). Only 4 patients were symptomatic (abdominal pain, 3 cases; melena, 1 case). The metastasis was metachronous in 11 cases, with mean disease-free interval of 9 years. The preoperative diagnosis was endocrine tumor in 4 cases. All patients underwent complete extirpation. At the time of follow-up, 3 patients had died of malignancy and 9 were still alive and free of disease, with a mean follow-up of 3 years.
Isolated metastatic tumors to the pancreas may be detected decades after the initial diagnosis and can be asymptomatic, emphasizing the need for lifelong surveillance in this population. Surgical extirpation of these lesions may offer the chance of long-term survival.
胰腺转移瘤较为罕见，通常是晚期转移疾病的一部分。孤立性转移瘤更为罕见，可能难以与原发性胰腺肿瘤相区别。转移的主要来源是乳腺、肺、肾和皮肤（黑色素瘤）。我们报告了 12 例孤立性胰腺转移瘤的经验。
我们对过去十年中发生的转移性疾病的胰腺切除术进行了回顾性分析。
起源部位如下：肾（8 例）、肺（2 例）、骨（1 例）和乳腺（1 例）。仅有 4 例患者有症状（腹痛 3 例；黑便 1 例）。11 例转移是异时性的，无病间期平均为 9 年。术前诊断为内分泌肿瘤 4 例。所有患者均行完全切除术。随访时，3 例患者死于恶性肿瘤，9 例患者仍存活且无疾病，平均随访 3 年。
孤立性胰腺转移瘤可能在最初诊断后数十年才被发现，且可能无症状，这强调了在这类人群中需要终身监测。这些病变的手术切除可能提供长期生存的机会。
