环磷酸腺苷与体内速发型超敏反应期间白细胞溶酶体酶释放的机制。
Cyclic AMP and the mechanism of leucocyte lysosomal enzyme release during an immediate hypersensitivity reaction in vivo.
作者信息
Deporter D A
出版信息
J Pathol. 1977 Nov;123(3):129-34. doi: 10.1002/path.1711230302.
The pleural cavity of rats was used to study the effect of altering leucocyte cyclic AMP content on the release of B-glucuronidase activity during an immediate hypersensitivity reaction. The effect on intravenous colchicine was also studied. Despite an increase of 135 to 235% in leucocyte cyclic AMP content no decrease in B-glucuronidase release was observed. Similarly, colchicine had no effect on enzyme release. It was concluded that the cyclic nucleotides and leucocyte microtubules may have no significant role to play in the release of lysosomal enzymes during acute inflammation in vivo.
利用大鼠的胸腔来研究在速发型超敏反应期间改变白细胞环磷酸腺苷（cAMP）含量对β-葡萄糖醛酸酶活性释放的影响。同时也研究了静脉注射秋水仙碱的作用。尽管白细胞环磷酸腺苷含量增加了135%至235%，但未观察到β-葡萄糖醛酸酶释放减少。同样，秋水仙碱对酶的释放也没有影响。得出的结论是，环核苷酸和白细胞微管在体内急性炎症期间溶酶体酶的释放中可能没有显著作用。
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