环磷腺苷与体内白细胞趋化性
Cyclic adenosine 3',5'-monophosphate and leucocyte chemotaxis in vivo.
作者信息
Deporter D A
出版信息
Br J Pharmacol. 1977 Jun;60(2):205-7. doi: 10.1111/j.1476-5381.1977.tb07742.x.
Abstract
1 The effect of local elevation of leucocyte cyclic adenosine 3',5'-monophosphate (cyclic AMP) content on the continued migration of leucocytes to a site of acute inflammation was studied in the pleural cavity of rats. 2 Leucocyte cyclic AMP levels were elevated by injecting with the irritant into the pleural cavity dibutyryl cyclic AMP alone or with theophylline. 3 The treatments both produced a marked reduction in leucocyte migration into a pleural reaction induced by immediate hypersensitivity, but had no effect on cell numbers in pleurisy induced either by pyrophosphate or urate crystals.
摘要
- 在大鼠胸腔中研究了局部提高白细胞环磷腺苷（环磷酸腺苷）含量对白细胞持续向急性炎症部位迁移的影响。2. 通过向胸腔注射单独的二丁酰环磷腺苷或与茶碱一起注射来提高白细胞环磷酸腺苷水平。3. 这两种处理均使白细胞向由速发型超敏反应诱导的胸膜反应中的迁移显著减少，但对由焦磷酸或尿酸盐晶体诱导的胸膜炎中的细胞数量没有影响。
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Effects of modification of intracellularcyclic AMP levels on the imediate hypersensitivity reaction in vivo.
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